Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor.
説明 | COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. |
In vitro | COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor[3]. |
In vivo | COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1].COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. |
分子量 | 337.82 |
分子式 | C16H16ClNO3S |
CAS No. | 544450-68-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (98.66 mM)
You can also refer to dose conversion for different animals. 詳細
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COR659 544450-68-2 GPCR/G Protein Membrane transporter/Ion channel Neuroscience Cannabinoid Receptor GABA Receptor Gamma-aminobutyric acid Receptor sucrose inhibit chocolate γ-Aminobutyric acid Receptor COR 659 Inhibitor COR-659 alcohol inhibitor