Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
説明 | CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM. |
ターゲット&IC50 | ATX:0.014 μM |
In vitro | CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM[1]. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM)[1]. |
In vivo | CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase[1].CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg[1]. |
別名 | CRT 0273750, CRT-0273750 |
分子量 | 502.92 |
分子式 | C25H22ClF3N4O2 |
CAS No. | 1979939-16-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/ml(397.68 mM)
You can also refer to dose conversion for different animals. 詳細
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CRT0273750 1979939-16-6 Metabolism PDE CRT 0273750 blood ATX/LPA 4T1 CRT-0273750 Inhibitor inhibit clearance LPA inhibitor