Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
説明 | CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells). |
ターゲット&IC50 | HepG2 cells:6.1 nM, Microsomal (rat):38 nM |
In vivo | CVT-12012 is highly potent in a human cell-based (HEPG2) SCD assay (IC(50)=6nM). This compound has 78% oral bioavailability in rats and is preferentially distributed into liver (76 times vs plasma) with relatively low brain penetration[1]. |
分子量 | 434.41 |
分子式 | C21H21F3N4O3 |
CAS No. | 1018675-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (287.75 mM)
You can also refer to dose conversion for different animals. 詳細
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CVT-12012 1018675-35-8 Metabolism Stearoyl-CoA Desaturase (SCD) CVT 12012 inhibit Inhibitor CVT12012 inhibitor