Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 7,500 | |||
10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 16,000 | |||
50 mg | 在庫あり | ¥ 18,500 | |||
100 mg | 在庫あり | ¥ 29,500 | |||
200 mg | 在庫あり | ¥ 42,500 |
説明 | Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis. |
In vitro | Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3] |
In vivo | Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5] |
キナーゼ試験 | EGFR kinase assays: In vitro inhibitory enzyme kinetic assays using recombinant EGFR L858R/T790M and WT protein and are performed using the ATP/NADH coupled assay system in a 96-well format. WZ4002 is added to determine its inhibitory effects. |
別名 | HPMPC, GS 0504, (S)-HPMPC |
分子量 | 279.19 |
分子式 | C8H14N3O6P |
CAS No. | 113852-37-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mg/mL (17.91 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble) (3.58 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cidofovir 113852-37-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis Inhibitor HPMPC Endogenous Metabolite Apoptosis GS 0504 inhibit cancer retinitis GS-0504 antiviral GS0504 CMV (S)-HPMPC Orthopoxvirus Cytomegalovirus herpes inhibitor