|
T9648 |
SIRT1-IN-1
|
|
Antiviral
,
Sirtuin
|
|
SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity. |
|
T38514 |
PMEDAP
|
|
Others
,
HIV Protease
|
|
PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega... |
|
T0718 |
Brivudine
|
Bromovinyldeoxyuridine,BVDU |
Others
,
HSV
|
|
Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster. |
|
T15235 |
Enocitabine
|
|
Nucleoside Antimetabolite/Analog
,
HCV Protease
,
DNA/RNA Synthesis
|
|
Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a ... |
|
T7659 |
Bisindolylmaleimide IV
|
|
Others
,
PKC
|
|
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM) |
|
T14324 |
Artemisone
|
BAY 44-9585,Artemifone |
Others
,
Parasite
|
|
Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV. |
|
T2162 |
Maribavir
|
BW1263W94,GW257406X,Benzimidavir,1263W94 |
Others
,
HCV Protease
|
|
Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nucle... |
|
T5396 |
Letermovir
|
AIC246,MK-8828 |
Others
,
HCV Protease
|
|
Letermovir (AIC246) (AIC246) is a novel anti-CMV compound (EC50: about 5 nM in fibroblast cells). It targets the pUL56 subunit of the viral terminase complex. |
|
T1533 |
Valganciclovir hydrochloride
|
Valganciclovir HCl,Valcyt,Valcyte |
Others
,
Antiviral
|
|
Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, v... |
|
T0220 |
Foscarnet sodium
|
Phosphonoformate |
Virus Protease
,
Reverse Transcriptase
,
DNA/RNA Synthesis
|
|
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. |
|
TQ0095 |
Brincidofovir
|
CMX001,HDP-CDV |
Others
,
Antiviral
,
HSV
|
|
Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses. |
|
T6593 |
ML324
|
|
Histone Demethylase
,
Others
,
HSV
|
|
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). |
|
T39477 |
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
|
Ca-DTPA trisodium salt hydrate |
Others
|
|
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Ca-DTPA tris... |
|
T8972 |
FIT-039
|
|
Others
,
DNA/RNA Synthesis
,
CDK
,
HSV
|
|
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr... |
|
T6244 |
Cidofovir
|
HPMPC,GS 0504,(S)-HPMPC |
Others
,
DNA/RNA Synthesis
|
|
Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis. |
|
T8736 |
Cidofovir dihydrate
|
HPMPC,(S)-HPMPC,GS 0504 |
Others
|
|
Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ... |
|
T0964 |
Floxuridine
|
5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
Others
,
DNA/RNA Synthesis
,
Antibacterial
,
HSV
|
|
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
|
T0688 |
Ganciclovir
|
BW 759,RS-21592,2'-Nor-2'-deoxyguanosine |
Nucleoside Antimetabolite/Analog
,
Others
,
Antibiotic
,
Antifection
,
HSV
|
|
Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegaloviru... |
|
T22337 |
Ganciclovir sodium
|
RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium |
Nucleoside Antimetabolite/Analog
,
Others
,
Antifection
,
HSV
|
|
Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1). |
|
T10445 |
B220
|
|
HSV
|
|
B220, an antiviral agent, inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV). |
|
T67788 |
BAY-43-9695
|
|
HCV Protease
|
|
BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766. |
|
TP1687L |
CEF20 acetate(153045-21-7 free base)
|
|
Others
|
|
CEF20 acetate is a CEF control peptide pool, is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). |
|
TP1822L |
CEF6 acetate(913545-15-0 free base)
|
|
Influenza Virus
|
|
CEF6 acetate is a HLA-B7 restricted influenza virus nucleoprotein epitope, belongs to the CEF control peptides. The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human cytomegalovir... |
|
T28905 |
T-611 free base
|
T-0902611,T-2611,T0902611,T-902611,T2611,T-611 |
|
|
T-611, a cytomegalovirus replication inhibitor, is used potentially for the treatment of cytomegalovirus infections. |
|
T69390 |
T-0902611 benzenesulfonate
|
|
|
|
T-0902611 benzenesulfonate is a cytomegalovirus replication inhibitor that may be useful in the treatment of cytomegalovirus infections. |
|
T28767 |
SGM8
|
|
|
|
SGM8 is a covalent allosteric inhibitor of human cytomegalovirus DNA polymerase subunit Interactions. |
|
T69396 |
MLS000108969
|
|
|
|
MLS000108969 is a novel inhibitor of human cytomegalovirus. |
|
T71066 |
Cidofovir sodium
|
|
|
|
Cidofovir sodium is the salt form of Cidofovir, a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor that is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis in... |
|
T15028 |
Cyclopropavir
|
MBX-400,Filociclovir,ZSM-I-62 |
Others
|
|
Cyclopropavir (Filociclovir; MBX-400) is a compound of broad-spectrum anti-herpesvirus. It has good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8 (EC50s: 0.7 μM to 8 μM). |
|
TP1687 |
CEF20
|
|
|
|
CEF20, a CEF control peptide pool, is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). |
|
T61840 |
PUL89 Endonuclease-IN-2
|
|
|
|
pUL89 Endonuclease-IN-2 (Compound 15k) is a highly effective inhibitor of the pUL89 endonuclease of human cytomegalovirus (HCMV). With an IC50 of 3.0 μM, it exhibits potent antiviral activities [1]. |
|
T77146 |
Regavirumab
|
|
|
|
Regavirumab (MCA C23), a human monoclonal antibody, targets cytomegalovirus (CMV), human serum albumin (HSA), and amino acetic acid [1]. |
|
T39068 |
Fomivirsen sodium
|
|
|
|
Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrad... |
|
T70514 |
Ganciclovir monophosphonate
|
|
|
|
Ganciclovir monophosphonate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is ef... |
|
TP1822 |
CEF6
|
|
|
|
CEF6, a HLA-B7 restricted influenza virus nucleoprotein epitope, belongs to the CEF control peptides. The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human cytomegalovirus, Epstei... |
|
T68495 |
Ganciclovir triphosphate
|
|
|
|
Ganciclovir triphosphate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effec... |
|
T60379 |
PUL89 Endonuclease-IN-1
|
|
|
|
pUL89 Endonuclease-IN-1 (Compound 13d), with an IC50 value of 0.88 μM, serves as a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease, demonstrating antiviral activity [1]. |
|
T77168 |
Sevirumab
|
|
|
|
Sevirumab (MSL-109), a human IgG1 monoclonal antibody, neutralizes cytomegalovirus (CMV) by specifically targeting CMV gH complexes, effectively inhibiting viral replication with an EC50 value of 0.3 μg/mL [1] [2]. |
|
T60419 |
Cyclic HPMPC
|
|
|
|
Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcom... |
|
T77010 |
Fiztasovimab
|
|
|
|
Fiztasovimab (NPC-21; EV2038), a fully human IgG1λ monoclonal antibody (mAb), targets human cytomegalovirus (hCMV). It exerts its neutralizing activity through binding to the antigenic domain 1 of glycoprotein B on the h... |
|
T73983 |
Cidofovir diphosphate tri(triethylamine)
|
|
|
|
Cidofovir diphosphate triethylamine, an active intracellular metabolite of Cidofovir, acts as a selective inhibitor of viral DNA polymerases. It exhibits inhibitory constants (K_i) of 6.6 μM for human cytomegalovirus (HC... |
|
T82701 |
CMV pp65(13-27)
|
|
|
|
CMV pp65(13-27) is a bioactive peptide derived from the 65k lower matrix phosphoprotein of the human cytomegalovirus, specifically comprising amino acid residues 13 to 27. It includes a nine-amino-acid sequence (LGPISGHV... |
|
T72385 |
LDC4297 hydrochloride
|
|
|
|
LDC4297 hydrochloride is a selective CDK7 inhibitor, characterized by an IC50 of 0.13 nM, demonstrating potent efficacy against human cytomegalovirus (HCMV) replication with an EC50 of 24.5 nM. It features broad antivira... |
|
T61259 |
Valganciclovir
|
|
|
|
Valganciclovir, the L-valyl ester of ganciclovir, is a prodrug effectively converted to ganciclovir in the body, serving as an antiviral medication for cytomegalovirus (CMV) infections. In vitro studies demonstrate that ... |
|
T60488 |
Ganciclovir hydrate
|
|
|
|
Ganciclovir (BW 759) hydrate is a nucleoside analogue that is an orally active antiviral agent with anti-cytomegalovirus activity. Ganciclovir hydrate is also active against members of the herpes group and some other DNA... |
|
T36673 |
CC 401 dihydrochloride
|
|
|
|
High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase... |
