Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 33,500 | |||
5 mg | 在庫あり | ¥ 68,500 | |||
10 mg | 在庫あり | ¥ 103,000 | |||
25 mg | 在庫あり | ¥ 170,000 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 317,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 81,000 |
説明 | Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm. |
In vitro | In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors. |
別名 | 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base), Compound 3344 hydrochloride (2368246-78-8 free base) |
分子量 | 426.94 |
分子式 | C24H27ClN2O3 |
CAS No. | T9184L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (140.53 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Compound 3344 hydrochloride T9184L GPCR/G Protein MAPK Ras 2368246-78-8 free base Compound 3344 Hydrochloride 2368246-78-8 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base) Compound 3344 hydrochloride (2368246-78-8 free base) Inhibitor inhibitor inhibit