Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,000 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 68,500 | |||
25 mg | 在庫あり | ¥ 130,500 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 54,500 |
説明 | DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM). |
ターゲット&IC50 | KDM1A/LSD1:84 nM |
In vitro | DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. DDP-38003 inhibits KDM1A (IC50: 84 nM) [1]. |
In vivo | DDP-38003, an oral anticancer candidate, possesses a half-life of 8 hours and demonstrates in vivo efficacy, resulting in a 62% survival increase in mouse leukemia models through KDM1A inhibition. The treatment's efficacy is dose-dependent, with survival rates augmenting by 35% and 62% at doses of 11.25 mg/kg and 22.50 mg/kg, respectively[1]. |
分子量 | 423.38 |
分子式 | C21H28Cl2N4O |
CAS No. | 1831167-98-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27mg/mL (63.8mM)
You can also refer to dose conversion for different animals. 詳細
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DDP-38003 dihydrochloride 1831167-98-6 Chromatin/Epigenetic Histone Demethylase DDP-38003 DDP 38003 Dihydrochloride DDP-38003 Dihydrochloride DDP 38003 dihydrochloride DDP 38003 DDP38003 dihydrochloride DDP38003 DDP38003 Dihydrochloride Inhibitor inhibitor inhibit