Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
説明 | DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
ターゲット&IC50 | DHODH:5.03(pKa) |
In vitro | A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure. |
分子量 | 265.27 |
分子式 | C15H11N3O2 |
CAS No. | 1263303-95-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (94.24 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DHODH-IN-11 1263303-95-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Dehydrogenase DNA/RNA Synthesis antiinflammatory DHODH IN 11 Inhibitor Leflunomide Rat DHODHIN11 cyano-oximes Dihydroorotate Dehydrogenase inhibit DHODH inhibitor