Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 28,500 | |||
25 mg | 在庫あり | ¥ 45,000 | |||
50 mg | 在庫あり | ¥ 72,500 | |||
100 mg | 在庫あり | ¥ 117,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 24,000 |
説明 | Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. |
ターゲット&IC50 | IDH1 (R132H):12 nM |
In vitro | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1]. |
細胞研究 | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference) |
別名 | AG-120 |
分子量 | 582.96 |
分子式 | C28H22ClF3N6O3 |
CAS No. | 1448347-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mg/mL (171.54 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (85.77 mM)
You can also refer to dose conversion for different animals. 詳細
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Ivosidenib 1448347-49-6 Metabolism Dehydrogenase Isocitrate Dehydrogenase (IDH) inhibit AG 120 Inhibitor AG120 AG-120 inhibitor