Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 63,000 | |||
25 mg | 在庫あり | ¥ 127,500 | |||
50 mg | 在庫あり | ¥ 183,500 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 42,000 |
説明 | AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects. |
ターゲット&IC50 | DHODH:17 nM |
In vitro | AG-636, in cancer cell lines of hematologic versus solid tumor origin.?Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model |
In vivo | AG-636 (10-100 mg/kg ;?oral gavage;?twice daily;?for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model |
分子量 | 343.38 |
分子式 | C21H17N3O2 |
CAS No. | 1623416-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (91.01 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AG-636 1623416-31-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Dehydrogenase DNA/RNA Synthesis inhibit oral reversible DHODH anticancer AG636 Inhibitor Dihydroorotate Dehydrogenase AG 636 inhibitor