Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
説明 | DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07. |
In vitro | A compound structurally related to leflunomide was designed, which contained a furan ring. Compound 12a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanoxime DHODH-IN-12. DHODH-IN-12 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the poor stereochemistry of the oxime substructure[1]. |
分子量 | 203.2 |
分子式 | C10H9N3O2 |
CAS No. | 1263303-93-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (295.28 mM)
You can also refer to dose conversion for different animals. 詳細
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DHODH-IN-12 1263303-93-0 Metabolism Dehydrogenase DHODHIN12 DHODH IN 12 Inhibitor inhibitor inhibit