Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,500 | |||
5 mg | 在庫あり | ¥ 78,000 | |||
10 mg | 在庫あり | ¥ 127,500 | |||
25 mg | 在庫あり | ¥ 206,000 | |||
50 mg | 在庫あり | ¥ 282,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1]. |
ターゲット&IC50 | TrkA:407 nM (IC50), MET:104 nM (IC50), Mer:63 nM (IC50), Axl:1.3 nM (IC50) |
In vitro | DS-1205 (0.3-33 μM; 2-24 h) inhibits hGAS6-induced migration in NIH3T3-AXL cells (EC50=2.7 nM)[1]. DS-1205 (1-10000 μM; 2-24 h) significantly inhibits the phosphorylation of AXL in NIH3T3-AXL cells. DS-1205 decreases NIH3T3 cell proliferation but not obviously inhibits growth (GI50>10,000 nM)[1]. |
In vivo | DS-1205 (3.1-50 mg/kg; p.o. bid for 5 d) exhibits pAXL inhibition mediated antitumor effects in mice[1]. |
分子量 | 735.8 |
分子式 | C41H42FN5O7 |
CAS No. | 1855860-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (61.16 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DS-1205 1855860-24-0 Tyrosine Kinase/Adaptors TAM Receptor TRKA c-Met/HGFR migration Axl Tyro3 DS1205 Trk Receptor MET Mer Tropomyosin related kinase receptor DS 1205 tumor kinase inhibit Inhibitor DS-1205b NIH3T3 inhibitor