Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
説明 | UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively. |
ターゲット&IC50 | Mer:4.3 nM |
In vitro | In mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%. |
In vivo | UNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation. |
分子量 | 463.58 |
分子式 | C25H33N7O2 |
CAS No. | 1493764-08-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 85 mg/mL (183.4 mM)
Ethanol: 5 mg/mL (10.78 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UNC2881 1493764-08-1 Tyrosine Kinase/Adaptors TAM Receptor Mer phosphorylation inhibit orally active UNC-2881 Tyro3 pathologic thrombosis Axl UNC 2881 Inhibitor platelet aggregation inhibitor