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検索結果

Search Results for " Tyro3 "

ターゲット

TAM Receptor

30

阻害剤

13

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T13074 TAM-IN-2 TAM Receptor
TAM-IN-2 is an inhibitor of TAM.
T1968 UNC2250 TAM Receptor
UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).
T6982 SGI-7079 FLT , c-Met/HGFR , c-RET , TAM Receptor , Src
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.
T2311 LDC1267 TAM Receptor
LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
T17205 UNC2541 Others , FLT , TAM Receptor
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
T2005 Dubermatinib TP0903 Apoptosis , TAM Receptor
Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
TQ0041 Ningetinib Tosylate VEGFR , c-Met/HGFR , TAM Receptor
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
T2629 UNC2881 TAM Receptor
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
T6907 NPS-1034 NPS1034,NPS 1034 Apoptosis , c-Met/HGFR , TAM Receptor
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
T7425 RU-301 TAM Receptor
RU-301 is a novel pan-tam inhibitor
T21302 UNC569 UNC 569 TAM Receptor
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun...
T4426 CEP-40783 CEP 40783,RXDX-106 c-Met/HGFR , TAM Receptor
CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
T9123 DS-1205 TAM Receptor
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...
T6269 Bemcentinib R428,BGB324 TAM Receptor
Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
T2699 BMS 777607 BMS777607,BMS-777607,BMS 817378 c-Met/HGFR , TAM Receptor
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3 (IC50: 3.9/1.1/1.8/4.3 nM). BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.
TQ0021 Ningetinib CT-053,CT053PTSA VEGFR , c-Met/HGFR , TAM Receptor
Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
T8327 ONO-7475 Trk receptor , TAM Receptor
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T4409 Gilteritinib ASP2215 FLT , TAM Receptor , c-Kit
Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...
T7379 2-D08 E1/E2/E3 Enzyme , TAM Receptor
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T9052 XL092 CL-092,JUN04542 VEGFR , c-Met/HGFR , TAM Receptor
XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.
T2586 Cabozantinib XL184,BMS-907351 Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T5164 Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T21302L UNC 569 hydrochloride UNC 569 hydrochloride (1350547-65-7 Free base) TAM Receptor , TAM Receptor
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydr...
T7007 UNC2025 mrx-6313,UNC-2025,UNC 2025 FLT , TAM Receptor
UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.
T60197 UNC 1025 Others
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format...
T5414 Glumetinib SCC244 c-Met/HGFR
Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).
T64185 TAM&Met-IN-1
TAM&Met-IN-1 is a potent inhibitor of TAM and c-Met, acting on AXL (IC50: 6.1 nM), MER (IC50: 13.2 nM) and TYRO3 (IC50: 21.6 nM). TAM&Met-IN-1 can be used in anticancer studies.
T63444 UNC4203
UNC4203 is a potent, highly selective, orally active MERTK inhibitor that acts on MERTK (IC50: 1.2 nM), AXL (IC50: 140 nM), TYRO3 (IC50: 42 nM) and FLT3 (IC50: 90 nM).
T9134 UNC5293
UNC5293 is a potent, orally available and highly MERTK-selective inhibitor with Ki of 190 pM. UNC5293 inhibits MERTK ( IC 50 =0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK pr...
T64080 C-Met-IN-12
c-Met-IN-12 is a selective, orally active type II c-Met kinase inhibitor (IC50: 10.6 nM). c-Met-IN-12 is a high inhibitor of AXL, Mer and TYRO3 kinases (>80% inhibition at 1 μM). c-Met-IN-12 can be used as a scaffold to ...

Compounds

TAM-IN-2
T13074
Synonym:
Target: TAM Receptor
UNC2250
T1968
Synonym:
Target: TAM Receptor
SGI-7079
T6982
Synonym:
Target: FLT, c-Met/HGFR, c-RET, TAM Receptor, Src
LDC1267
T2311
Synonym:
Target: TAM Receptor
UNC2541
T17205
Synonym:
Target: Others, FLT, TAM Receptor
Dubermatinib
T2005
Synonym: TP0903
Target: Apoptosis, TAM Receptor
Ningetinib Tosylate
TQ0041
Synonym:
Target: VEGFR, c-Met/HGFR, TAM Receptor
UNC2881
T2629
Synonym:
Target: TAM Receptor
NPS-1034
T6907
Synonym: NPS1034,NPS 1034
Target: Apoptosis, c-Met/HGFR, TAM Receptor
RU-301
T7425
Synonym:
Target: TAM Receptor
UNC569
T21302
Synonym: UNC 569
Target: TAM Receptor
CEP-40783
T4426
Synonym: CEP 40783,RXDX-106
Target: c-Met/HGFR, TAM Receptor
DS-1205
T9123
Synonym:
Target: TAM Receptor
Bemcentinib
T6269
Synonym: R428,BGB324
Target: TAM Receptor
BMS 777607
T2699
Synonym: BMS777607,BMS-777607,BMS 817378
Target: c-Met/HGFR, TAM Receptor
Ningetinib
TQ0021
Synonym: CT-053,CT053PTSA
Target: VEGFR, c-Met/HGFR, TAM Receptor
ONO-7475
T8327
Synonym:
Target: Trk receptor, TAM Receptor
Gilteritinib
T4409
Synonym: ASP2215
Target: FLT, TAM Receptor, c-Kit
2-D08
T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
XL092
T9052
Synonym: CL-092,JUN04542
Target: VEGFR, c-Met/HGFR, TAM Receptor
Cabozantinib
T2586
Synonym: XL184,BMS-907351
Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit
Cabozantinib hydrochloride
T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
UNC 569 hydrochloride
T21302L
Synonym: UNC 569 hydrochloride (1350547-65-7 Free base)
Target: TAM Receptor, TAM Receptor
UNC2025
T7007
Synonym: mrx-6313,UNC-2025,UNC 2025
Target: FLT, TAM Receptor
UNC 1025
T60197
Synonym:
Target: Others
Glumetinib
T5414
Synonym: SCC244
Target: c-Met/HGFR
TAM&Met-IN-1
T64185
Synonym:
Target:
UNC4203
T63444
Synonym:
Target:
UNC5293
T9134
Synonym:
Target:
c-Met-IN-12
T64080
Synonym:
Target:

Recombinant Proteins

Species：
Human (6)
Mouse (4)
Cynomolgus (3)
Expression System：
HEK293 Cells (13)
Tag：
C-His (5)
C-6xHis (2)
C-His-Avi (2)
C-hFc (2)
C-Avi-6xHis (1)
C-mFc (1)
カタログ番号 製品名 Species Expression System
TMPK-00901 TYRO3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
TYRO3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 43 kDa and the accession number is P55144-2.
TMPK-00533 TYRO3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
TYRO3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 42.47 kDa and the accession number is A0A2K5WCY8.
TMPJ-01018 Dtk Protein, Mouse, Recombinant (mFc) Mouse HEK293 Cells
Dtk Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is P55144.
TMPJ-01017 Dtk Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Dtk Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P55144.
TMPJ-01081 Dtk Protein, Human, Recombinant (His) Human HEK293 Cells
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs an...
TMPY-04830 GAS6 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPK-00472 AXL Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00517 GAS6 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of ...
TMPK-00407 AXL Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00410 AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated Human HEK293 Cells
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00408 AXL Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPJ-00365 GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated Human HEK293 Cells
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa...
TMPJ-01143 MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) Human HEK293 Cells
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one...
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