|
T73300 |
AXL-IN-13
|
|
FLT
,
TAM Receptor
,
PDGFR
,
TGF-beta/Smad
|
|
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh... |
|
T63293 |
Axl-IN-7
|
|
|
|
Axl-IN-7 is a potent inhibitor of AXL. Axl-IN-7 can be used to study Axl-related diseases such as cancer (e.g., acute myeloid leukemia, breast cancer, melanoma, pancreatic cancer, and glial tumors), immune system disorde... |
|
T63683 |
Axl-IN-11
|
|
|
|
Axl-IN-11 is a potent inhibitor of AXL. Axl-IN-11 can be used to study proliferative diseases, allergic diseases, autoimmune diseases, inflammatory diseases, cancer, transplant rejection, viral infectious diseases or oth... |
|
T63154 |
Axl-IN-10
|
|
|
|
Axl-IN-10 is a potent inhibitor of AXL (IC50: 5 nM).Axl-IN-10 has good pharmacokinetic properties in animals and excellent transmembrane properties.Axl-IN-10 can be used to study proliferative, allergic, autoimmune, infl... |
|
T79969 |
Axl-IN-16
|
|
TAM Receptor
|
|
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1]. |
|
T73310 |
AXL-IN-14
|
|
TAM Receptor
|
|
AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6/AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates... |
|
T63320 |
Axl-IN-6
|
|
|
|
Axl-IN-6 is an orally active inhibitor of AXL. Axl-IN-6 demonstrated good tolerance and significant inhibition of tumor growth in the MV-4-11 subcutaneous xenograft tumor model. |
|
T63901 |
Axl-IN-8
|
|
|
|
Axl-IN-8 (NO.1) is a potent inhibitor of AXL (IC50<1 nM) and also inhibits c-MET (IC50: 1-10 nM). : 120.3 nM). |
|
T62778 |
Axl-IN-9
|
|
|
|
Axl-IN-9 is a potent inhibitor of AXL (IC50: 26 nM) with excellent transmembrane properties.Axl-IN-9 exhibits good pharmacokinetic properties in animals.Axl-IN-9 can be used to study proliferative, autoimmune, allergic, ... |
|
T60259 |
Axl-IN-4
|
|
|
|
Axl-IN-4 (Compound 24) is an inhibitor of AXL kinase with an IC 50 of 28.8 μM [1]. |
|
T63817 |
Axl-IN-5
|
|
|
|
Axl-IN-5 (compound 1) is an AXL inhibitor (IC50: 283 nM) that exhibits anticancer activity. |
|
T63888 |
Axl-IN-12
|
|
|
|
Axl-IN-12 is a potent inhibitor of AXL. Axl-IN-12 can be used to study proliferative, allergic, autoimmune, inflammatory, cancer, transplant rejection, viral infectious diseases or other mammalian diseases. |
|
T62962 |
Axl-IN-3
|
|
|
|
Axl-IN-3 is a selective, potent and orally active inhibitor of AXL kinase (IC50: 41.5 nM) and has a low inhibitory effect on other kinases. |
|
T79045 |
AXL-IN-15
|
|
TAM Receptor
|
|
AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1 nanomolar (nM). It is applicable for cancer research [1]. |
|
T72574 |
Axl/Mer/CSF1R-IN-1
|
|
|
|
Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM. |
|
T74354 |
PROTAC Axl Degrader 2
|
|
|
|
PROTAC Axl Degrader 2, a potent and selective PROTAC Axl degrader, demonstrates an IC50 of 1.61 µM. It exhibits anti-proliferative and anti-migratory activities in vitro and induces mehuosis [1]. |
|
T74353 |
PROTAC Axl Degrader 1
|
|
|
|
PROTAC Axl Degrader 1 is a potent, selective degrader of PROTAC Axl, exhibiting an IC50 of 0.92 µM. It demonstrates in vitro anti-proliferative and anti-migratory activities and induces mehuosis [1]. |
|
T6982 |
SGI-7079
|
|
FLT
,
c-Met/HGFR
,
c-RET
,
TAM Receptor
,
Src
|
|
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance. |
|
T1968 |
UNC2250
|
|
TAM Receptor
|
|
UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM). |
|
T13074 |
TAM-IN-2
|
|
TAM Receptor
|
|
TAM-IN-2 is an inhibitor of TAM. |
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T2311 |
LDC1267
|
|
TAM Receptor
|
|
LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM). |
|
T17205 |
UNC2541
|
|
Others
,
FLT
,
TAM Receptor
|
|
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM). |
|
T2005 |
Dubermatinib
|
TP0903 |
Apoptosis
,
TAM Receptor
|
|
Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor. |
|
TQ0041 |
Ningetinib Tosylate
|
|
VEGFR
,
c-Met/HGFR
,
TAM Receptor
|
|
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively. |
|
T12731 |
RIPK1-IN-7
|
|
RIP kinase
|
|
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. |
|
T6907 |
NPS-1034
|
NPS1034,NPS 1034 |
Apoptosis
,
c-Met/HGFR
,
TAM Receptor
|
|
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. |
|
T2629 |
UNC2881
|
|
TAM Receptor
|
|
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively. |
|
T7425 |
RU-301
|
|
TAM Receptor
|
|
RU-301 is a novel pan-tam inhibitor |
|
T21302 |
UNC569
|
UNC 569 |
TAM Receptor
|
|
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun... |
|
T4426 |
CEP-40783
|
CEP 40783,RXDX-106 |
c-Met/HGFR
,
TAM Receptor
|
|
CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM). |
|
T8327 |
ONO-7475
|
|
Trk receptor
,
TAM Receptor
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
|
T9123 |
DS-1205
|
|
TAM Receptor
|
|
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an... |
|
T6269 |
Bemcentinib
|
R428,BGB324 |
TAM Receptor
|
|
Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC. |
|
TQ0021 |
Ningetinib
|
CT-053,CT053PTSA |
VEGFR
,
c-Met/HGFR
,
TAM Receptor
|
|
Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively. |
|
T2699 |
BMS 777607
|
BMS777607,BMS-777607,BMS 817378 |
c-Met/HGFR
,
TAM Receptor
|
|
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3 (IC50: 3.9/1.1/1.8/4.3 nM). BMS-777607 has been investigated for the basic science of Malignant Solid Tumour. |
|
T4409 |
Gilteritinib
|
ASP2215 |
FLT
,
TAM Receptor
,
c-Kit
|
|
Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an... |
|
T7379 |
2-D08
|
|
E1/E2/E3 Enzyme
,
TAM Receptor
|
|
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect. |
|
T9052 |
XL092
|
CL-092,JUN04542 |
VEGFR
,
c-Met/HGFR
,
TAM Receptor
|
|
XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders. |
|
T2586 |
Cabozantinib
|
XL184,BMS-907351 |
Apoptosis
,
VEGFR
,
FLT
,
c-Met/HGFR
,
c-RET
,
TAM Receptor
,
c-Kit
|
|
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity... |
|
T4349 |
Sitravatinib
|
MG516,MGCD516 |
Discoidin Domain Receptor (DDR)
,
VEGFR
,
FLT
,
Trk receptor
,
TAM Receptor
,
c-Kit
,
Ephrin Receptor
|
|
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. |
|
T5164 |
Cabozantinib hydrochloride
|
XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 |
VEGFR
,
FLT
,
c-Met/HGFR
,
TAM Receptor
,
c-Kit
,
ROR
|
|
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM). |
|
TP1713 |
Axltide
|
|
|
|
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989).Peptide sequence (KKSRGDYMTMQIG) is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). |
|
T3274 |
S49076
|
|
FGFR
,
c-Met/HGFR
,
TAM Receptor
|
|
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs. |
|
T71973 |
Gilteritinib hemifumarate
|
ASP2215 hemifumarate |
FLT
,
TAM Receptor
|
|
Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of relapsed or refractory FLT3 mutant AML. |
|
T76864 |
Enapotamab
|
|
TAM Receptor
|
|
Enapotamab is an AXL/UFO-related antibody that can be used to synthesize antibody-drug couplings (Enapotamab Vedotin). |
|
T16806 |
RU-302
|
[2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone |
TAM Receptor
|
|
RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation of Gas6-inducible AXL and suppresses lung cancer tumor grow... |
|
T2617 |
SNS-314 Mesylate
|
SNS-314 |
Aurora Kinase
|
|
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
|
T21302L |
UNC 569 hydrochloride
|
UNC 569 hydrochloride (1350547-65-7 Free base) |
TAM Receptor
,
TAM Receptor
|
|
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydr... |
|
T7007 |
UNC2025
|
mrx-6313,UNC-2025,UNC 2025 |
FLT
,
TAM Receptor
|
|
UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3. |
|
T60197 |
UNC 1025
|
|
Others
|
|
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format... |
