Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydropachymic acid shows antiinflammatory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 32,000 | |||
5 mg | 在庫あり | ¥ 90,000 | |||
10 mg | 在庫あり | ¥ 136,500 | |||
25 mg | 在庫あり | ¥ 218,000 | |||
50 mg | 在庫あり | ¥ 296,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 112,000 |
説明 | Dehydropachymic acid shows antiinflammatory activity. |
In vitro | Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), Dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells. |
植物由来 |
分子量 | 526.75 |
分子式 | C33H50O5 |
CAS No. | 77012-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.27 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Dehydropachymic acid 77012-31-8 Autophagy Immunology/Inflammation Immunology/Inflammation related inhibit Inhibitor inhibitor