Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,000 | |||
50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 14,000 | |||
200 mg | 在庫あり | ¥ 20,500 | |||
500 mg | 在庫あり | ¥ 34,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic. |
ターゲット&IC50 | p300:996 μM |
In vitro | Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2]. |
In vivo | Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3]. |
細胞研究 | HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference) |
別名 | Flovacil, Dolobid, MK-647, Fluniget, Dolobis |
分子量 | 250.2 |
分子式 | C13H8F2O3 |
CAS No. | 22494-42-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (199.84 mM)
Ethanol: 20 mg/mL (79.94 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Diflunisal 22494-42-4 Chromatin/Epigenetic Immunology/Inflammation Neuroscience COX Epigenetic Reader Domain Flovacil Cyclooxygenase Dolobid MK 647 MK-647 Fluniget Inhibitor MK647 Dolobis inhibit inhibitor