Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 7,500 | |||
25 mg | 在庫あり | ¥ 11,000 | |||
50 mg | 在庫あり | ¥ 16,000 | |||
100 mg | 在庫あり | ¥ 22,500 | |||
200 mg | 在庫あり | ¥ 34,000 | |||
500 mg | 在庫あり | ¥ 58,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity |
In vitro | Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor[1]. |
細胞研究 | Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1]. |
分子量 | 252.31 |
分子式 | C10H8N2O2S2 |
CAS No. | 3696-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.52 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Dipyrithione 3696-28-4 Others dermatophytosis G1 phase antiproliferative antifungal Apoptosis Bacterial anti-inflammatory anti-tumor Fungal Inhibitor inhibit inhibitor