Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,500 |
5 mg | 在庫あり | ¥ 190,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 365,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases. |
In vivo | E-6801 (1.25-10 mg/kg; i.p.) produced significant and mostly dose-dependent increases in novel object exploration, indicative of memory enhancement. Furthermore, sub-effective doses of E-6801 (1 mg/kg) when co-administered with either SB-271046 (3 mg/kg), donepezil (0.1 mg/kg), or memantine (5 mg/kg) significantly enhanced object-recognition memory. Additionally, using a 1-min inter-trial delay, E-6801 (2.5 and 5 mg/kg) was as effective as donepezil (0.3 and 1 mg/kg) in reversing a scopolamine-induced (0.5 mg/kg) impairment in object recognition. This study demonstrates that E-6801, a potent 5-HT(6) receptor agonist, improves recognition memory by combining cholinergic and glutamatergic neurotransmission modulation.[1] |
別名 | E 6801, E-6801 |
分子量 | 423.94 |
分子式 | C17H18ClN5O2S2 |
CAS No. | 528859-04-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (106.15 mM)
You can also refer to dose conversion for different animals. 詳細
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E6801 528859-04-3 GPCR/G Protein Neuroscience 5-HT Receptor E 6801 E-6801 Inhibitor inhibitor inhibit