Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
説明 | EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity. |
In vitro | EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities[1]. |
In vivo | EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide)[1]. |
分子量 | 319.21 |
分子式 | C12H12Cl2N2O2S |
CAS No. | 1638526-21-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90mg/mL (281.9mM)
You can also refer to dose conversion for different animals. 詳細
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EMT inhibitor-1 1638526-21-2 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin EMT inhibitor1 EMT inhibitor 1 Inhibitor inhibitor inhibit