Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 104,500 | |||
50 mg | 在庫あり | ¥ 154,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 38,500 |
説明 | ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation. |
ターゲット&IC50 | EPAC2:8.4 μM |
In vitro | ESI-08 (25 μM) does not alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |
分子量 | 353.48 |
分子式 | C20H23N3OS |
CAS No. | 301177-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (141.45 mM)
You can also refer to dose conversion for different animals. 詳細
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ESI-08 301177-43-5 GPCR/G Protein cAMP EPAC2 exchange proteins ESI08 EPAC Ras inhibit EPAC1 ESI 08 Inhibitor inhibitor