Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 118,000 |
5 mg | 在庫あり | ¥ 229,000 |
10 mg | 在庫あり | ¥ 305,500 |
25 mg | 在庫あり | ¥ 457,000 |
50 mg | 在庫あり | ¥ 617,500 |
100 mg | 在庫あり | ¥ 831,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 229,000 |
説明 | Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells. |
In vitro | In this study, we demonstrated that Eriocalyxin B was efficacious in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Treatment with Eriocalyxin B led to amelioration of EAE, which correlated with reduced spinal cord inflammation and demyelination. Eriocalyxin B treatment abolished encephalitogenic T-cell responses to myelin oligodendrocyte glycoprotein in an adoptive transfer EAE model. The underlying mechanism of Eriocalyxin B-induced effects involved inhibition of T helper (Th) 1 and Th17 cell differentiation through Janus Kinase/Signal Transducer and Activator Of Transcription and Nuclear factor-κB signaling pathways as well as elevation of reactive oxygen species[1] |
植物由来 |
分子量 | 344.4 |
分子式 | C20H24O5 |
CAS No. | 84745-95-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (159.7 mM)
You can also refer to dose conversion for different animals. 詳細
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Eriocalyxin B 84745-95-9 Apoptosis GPCR/G Protein JAK/STAT signaling NF-Κb Stem Cells NF-κB STAT cAMP inhibit Inhibitor inhibitor