Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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10 mg | 在庫あり | ¥ 9,500 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 18,000 | |||
100 mg | 在庫あり | ¥ 26,000 | |||
200 mg | 在庫あり | ¥ 40,000 | |||
500 mg | 在庫あり | ¥ 67,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,500 |
説明 | Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker. |
ターゲット&IC50 | AT1 receptor:0.83 nM(Kd) |
In vitro | In a study involving brain and spinal cord injured rats, Eprosartan (0.3 mg/kg i.v.) was observed to induce a hypertensive response following spinal cord stimulation. |
In vivo | Eprosartan effectively inhibits [125I]-Angiotensin II in human tissues (adrenal cortex, liver, cloned AT1 receptors) with an IC50 range of 1.4-3.9 nM and in rat tissues (mesenteric artery, adrenal cortex, glomeruli) with an IC50 range of 1.5-9.2 nM. In isolated perfused proximal tubules of rabbits, Eprosartan (100 nM) completely blocks the isosmotic fluid absorption induced by Angiotensin II. |
別名 | SKF-108566J |
分子量 | 520.62 |
分子式 | C23H24N2O4S·CH4O3S |
CAS No. | 144143-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 4 mg/mL (7.68 mM)
DMSO: 104 mg/mL (199.76 mM)
You can also refer to dose conversion for different animals. 詳細
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Eprosartan Mesylate 144143-96-4 Endocrinology/Hormones RAAS inhibit angiotensin-II nonpeptid SKF-108566J antihypertensive Angiotensin Receptor Eprosartan AT1 Inhibitor inhibitor