Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.
説明 | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension. |
ターゲット&IC50 | DBH:107 nM |
In vitro | Etamicastat hydrochloride blocks the hERG current amplitude with an IC50 value of 44 μg/mL [1]. |
In vivo | Etamicastat hydrochloride (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat hydrochloride (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1]. |
細胞研究 | Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL . |
動物実験 | Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels. |
別名 | BIA 5-453 hydrochloride |
分子量 | 347.81 |
分子式 | C14H16ClF2N3OS |
CAS No. | 677773-32-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 15.0 mg/mL (43.1 mM), Sonication is recommended.
DMSO: 90.0 mg/mL (258.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Etamicastat hydrochloride 677773-32-9 Metabolism Dehydrogenase Etamicastat Hydrochloride BIA 5-453 Hydrochloride BIA 5-453 hydrochloride Inhibitor inhibitor inhibit