Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 8,000 | |||
10 mg | 在庫あり | ¥ 11,500 | |||
25 mg | 在庫あり | ¥ 16,500 | |||
50 mg | 在庫あり | ¥ 23,500 | |||
100 mg | 在庫あり | ¥ 36,000 | |||
200 mg | 在庫あり | ¥ 60,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. |
ターゲット&IC50 | COX-2:1.1 μM COX-1 |
In vivo | The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2]. |
細胞研究 | Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS. (Only for Reference) |
別名 | Arcoxia, MK-663, Tauxib, L-791456, Nucoxia, Desvenlafaxine |
分子量 | 358.84 |
分子式 | C18H15ClN2O2S |
CAS No. | 202409-33-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 43 mg/mL (119.8 mM)
DMSO: 50 mg/mL (139.34 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Etoricoxib 202409-33-4 Immunology/Inflammation Neuroscience COX MK-0663 L 791456 MK 0663 Arcoxia Inhibitor MK663 MK-663 Tauxib L-791456 inhibit MK0663 MK 663 Nucoxia Cyclooxygenase L791456 Desvenlafaxine inhibitor