Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 50,000 | |||
25 mg | 在庫あり | ¥ 83,500 | |||
50 mg | 在庫あり | ¥ 123,500 | |||
100 mg | 在庫あり | ¥ 179,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 37,000 |
説明 | Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma. |
In vitro | Flavokawain C (FKC) markedly decreased the cell viability of HT-29 cells and the cells showed dramatic changes in cellular and nuclear morphologies with typical apoptotic features.?The induction of apoptosis correlated well with the externalization of phosphatidylserine, DNA fragmentation, decreased mitochondrial membrane potential, activation of caspases, and PARP cleavage.?This was associated with an increase in reactive oxygen species and a decrease in SOD activity.?The protein levels of XIAP, c-IAP1, and c-IAP2 were downregulated, whereas the GADD153 was upregulated after FKC treatment.?FKC induced cell cycle arrest at the G1 and G2/M phases via upregulation of p21 and p27 in a p53-independent manner.??FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma[1]. |
細胞研究 | Cell viability of HT-29 cells was assessed by Sulforhodamine B assay after FKC treatment.?Induction of apoptosis was examined by established morphological and biochemical assays.?ROS generation was determined by dichlorofluorescein fluorescence staining, and superoxide dismutase activity was measured using the spectrophotometric method.?Western blotting was used to examine the changes in the protein levels[1]. |
植物由来 |
分子量 | 300.31 |
分子式 | C17H16O5 |
CAS No. | 37308-75-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (83.25 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Flavokawain C 37308-75-1 Apoptosis inhibit Inhibitor inhibitor