Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 34,000 |
5 mg | 約5 days | ¥ 57,000 |
10 mg | 約5 days | ¥ 95,000 |
1 mL * 10 mM (in DMSO) | 約5 days | ¥ 62,500 |
説明 | GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux. |
ターゲット&IC50 | KIF15:0.82 μM, ULK1:PIC50=6.37 |
In vitro | GW406108X were acting upon ULK1 and autophagy without affecting mTOR or AMPK activity as shown by monitoring ULK1 pS758 (mTOR site) or pS556 (AMPK site) levels[1]. |
別名 | GW108X |
分子量 | 400.21 |
分子式 | C20H11Cl2NO4 |
CAS No. | 1644443-92-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL(112.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GW406108X 1644443-92-4 Autophagy Cytoskeletal Signaling Kinesin ATP flux GW-406108X competitive Inhibitor U2OS inhibit GW108X ULK autophagic cells Unc-51 like kinase inhibitor