|
T5345 |
V-9302
|
|
Others
|
|
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). |
|
T9541 |
CTB
|
Cholera Toxin B subunit |
Epigenetic Reader Domain
|
|
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells. |
|
T7882 |
Indomethacin farnesil
|
Infree |
Others
,
COX
,
Autophagy
|
|
Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD). |
|
T41286 |
N6-Isopentenyladenosine
|
|
Endogenous Metabolite
,
Autophagy
|
|
N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different... |
|
T1434 |
Clarithromycin
|
A-56268 |
P450
,
ribosome
,
MRP
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... |
|
TQ0002 |
A-317491
|
ABT 202 |
P2X Receptor
|
|
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. |
|
T9207 |
GW406108X
|
GW108X |
Kinesin
,
Autophagy
|
|
GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux. |
|
T11307 |
Fluxametamide
|
|
GABA Receptor
|
|
Fluxametamide is a novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels, acts as an antagonist of GABA- and glutamate-gated chloride channels(IC50 of 1.95 nM and 225... |
|
T21136 |
Fluxapyroxad
|
|
Antifungal
|
|
Fluxapyroxad is a broad-spectrum fungicide that inhibits the succinate dehydrogenase (SQR) enzyme. |
|
T72521 |
Efflux inhibitor-1
|
|
|
|
Efflux inhibitor-1 is a pyrazolopyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC 50 s of 0.45 μM and 2.17 μM, respectively . |
|
T60036 |
ML-SA5
|
|
Autophagy
|
|
ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. |
|
T11142 |
EACC
|
|
Autophagy
|
|
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a... |
|
T24859 |
TC-AQP1-1
|
|
Aquaporin
|
|
TC-AQP1-1 is a blocker of the aquaporin 1 channel identified by virtual screening and inhibits water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations. |
|
T27060 |
CP-226269
|
CP 226269,CP226269 |
Dopamine Receptor
|
|
CP-226269 is a potent dopamine D4 receptor agonist that regulates calcium flux and has an EC50 value of 32.0 nM. CP 226269 can be used to study neurological disorders such as schizophrenia. |
|
T14688 |
BMS CCR2 22
|
|
CCR
|
|
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM. |
|
T68122 |
Oxmetidine
|
SKF 92994,Oxmetidina,Oxmetidinum |
Histamine Receptor
|
|
Oxmetidine (SKF 92994) is a novel H2 receptor antagonist that is cytotoxic. Oxmetidine inhibits transmembrane calcium flux in cardiac and vascular tissues and is used in the treatment of active duodenal ulcers. |
|
T13041 |
Surfactin
|
|
HSV
|
|
Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic eff... |
|
T41008 |
BODIPY-Cholesterol
|
BCh2 |
|
|
BODIPY-Cholesterol (TF-Chol) is a cholesterol analog with a fluorescent BODIPY motif and cellular permeability, and is a novel BODIPY cholesterol probe.BODIPY-Cholesterol can be used to study intracellular sterol uptake ... |
|
T3465L |
Vesnarinone HCl
|
Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base) |
Potassium Channel
,
Calcium Channel
,
PDE
|
|
Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new... |
|
T0802 |
Procaine hydrochloride
|
Novocaine HCl,Procaine HCl |
Histone Demethylase
,
5-HT Receptor
,
DNA/RNA Synthesis
,
Sodium Channel
,
NMDAR
,
AChR
|
|
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel... |
|
T3528 |
Senicapoc
|
ICA-17043 |
Potassium Channel
|
|
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 =... |
|
T11277 |
FG 7142
|
ZK 39106,LSU-65 |
GABA Receptor
|
|
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb... |
|
T1083L |
Theophylline monohydrate
|
Quibron |
HDAC
,
PDE
,
Adenosine Receptor
|
|
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... |
|
T14899 |
CCR1 antagonist 8
|
|
CCR
|
|
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). |
|
T10713 |
CCR4 antagonist 2
|
|
Calcium Channel
|
|
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n... |
|
T10710 |
CCR1 antagonist 9
|
|
CCR
|
|
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). |
|
T12819 |
S130
|
|
Cysteine Protease
|
|
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux. |
|
T14373 |
AZD2423
|
|
CCR
|
|
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3]. |
|
T28893 |
SX-517
|
SX 517 |
|
|
SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibits CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs. |
|
T24623 |
PF-06807656
|
PF 06807656 |
|
|
PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ fl... |
|
T36812 |
Linoleic Acid Amide
|
9,12-Octadecadienamide,Linoleamide,Linoleic Acid Amide |
Calcium Channel
|
|
Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase. |
|
T11452 |
GPR120 Agonist 1
|
|
GPR
|
|
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GPR120 (the calcium flux assay), respectively. |
|
T39662 |
CCR4 antagonist 3 hydrochloride
|
|
|
|
CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assa... |
|
T10204 |
A-317491 sodium salt hydrate
|
A-317491 sodium salt hydrate (475205-49-3 free base) |
Others
|
|
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
|
T60749 |
Autophagy-IN-2
|
|
|
|
Autophagy-IN-2 (Compound 7h) is an inhibitor of autophagic flux which induces cancer cell apoptosis and can be used for the research of triple-negative breast cancer [1]. |
|
T38157 |
Ricinelaidic Acid
|
|
|
|
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu... |
|
T39661 |
CCR4 antagonist 3
|
CCR4 antagonist 3 |
|
|
CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antago... |
|
T40064 |
V-9302 hydrochloride
|
|
|
|
V-9302 hydrochloride is a potent and selective competitive antagonist that inhibits transmembrane glutamine flux by specifically targeting the amino acid transporter ASCT2 (SLC1A5), and not ASCT1. In HEK-293 cells, V-930... |
|
T11966 |
MCHR1 antagonist 2
|
|
HER
,
Melanin-concentrating Hormone Receptor (MCHR)
|
|
|
|
T61420 |
CXCR4 antagonist 6
|
|
|
|
CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 anta... |
|
TP2141 |
Balixafortide TFA (1051366-32-5 free base)
|
Balixafortide TFA,POL6326 TFA |
CXCR
|
|
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-... |
|
T79668 |
PIK5-12d
|
|
Autophagy
|
|
PIK5-12d, a potent PROTAC PIKfyve degrader (DC50: 1.48 nM), effectively induces cytoplasmic vacuolization and inhibits autophagic flux in various prostate cancer cell lines, concurrently halting their proliferation. This... |
|
T65489 |
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride
|
|
|
|
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is used as a probe for luminescent detection and quantitation of oxygen (absorption λmax=455 nm, luminescence λmax=613 nm). It is also used for fibre optic s... |
|
TP2141L |
Balixafortide
|
POL6326 |
CXCR
|
|
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1]... |
|
T11896 |
LV-320
|
|
Cysteine Protease
|
|
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. Th... |
|
T36064 |
N-Oleoyl Glutamine
|
|
|
|
N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitocho... |
|
T35918 |
N-Arachidonoyl Taurine
|
|
|
|
N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is... |
|
T35922 |
NAADP (sodium salt)
|
|
|
|
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then... |
|
T14215 |
AMG 837 sodium salt
|
|
Others
|
|
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agoni... |
|
T62331 |
Autophagy-IN-1
|
|
|
|
Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t... |
