Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 32,000 | |||
5 mg | 在庫あり | ¥ 97,500 | |||
10 mg | 在庫あり | ¥ 142,000 | |||
25 mg | 在庫あり | ¥ 221,000 | |||
50 mg | 在庫あり | ¥ 296,000 | |||
100 mg | 在庫あり | ¥ 402,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 91,000 |
説明 | Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan |
In vitro | To find the candidate ingredients, we examined competitive binding assay and [(35)S] guanosine 5'-O-(3-thiotriphosphate) (GTPγS) binding assay of seven major alkaloids in UH using Chinese hamster ovary cells expressing 5-HT(1A) receptors artificially. Only Geissoschizine methyl ether (GM) among seven alkaloids potently bound to 5-HT(1A) receptors and acted as a partial agonist. This in vitro result on GM was further demonstrated in the socially isolated mice. As did YKS and UH, GM ameliorated the isolation-induced increased aggressiveness and decreased sociality, and the effect was counteracted by coadministration of WAY-100635[1] |
植物由来 |
分子量 | 366.45 |
分子式 | C22H26N2O3 |
CAS No. | 60314-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (30.02 mM)
You can also refer to dose conversion for different animals. 詳細
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Geissoschizine methyl ether 60314-89-8 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibit 5-hydroxytryptamine Receptor Serotonin Receptor inhibitor