Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
説明 | GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. |
ターゲット&IC50 | CFTR:4.3 μM(Ki) |
In vitro | GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3] |
In vivo | In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1] |
別名 | GlyH 101 |
分子量 | 493.15 |
分子式 | C19H15Br2N3O3 |
CAS No. | 328541-79-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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GlyH-101 328541-79-3 Autophagy Membrane transporter/Ion channel CFTR Inhibitor antiproliferative PCT inhibit PS120 cells GlyH101 intestinal fluid GlyH 101 VSORC CFTR-like current Cystic fibrosis transmembrane conductance regulator inhibitor