Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.
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10 mg | 在庫あり | ¥ 9,500 | |||
25 mg | 在庫あり | ¥ 15,500 | |||
50 mg | 在庫あり | ¥ 22,500 | |||
100 mg | お問い合わせ | ¥ 34,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine. |
In vivo | Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1]. |
分子量 | 175.14 |
分子式 | C5H9N3O4 |
CAS No. | 6133-30-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 6 mg/mL (34.26 mM)
DMSO: 75 mg/mL (428.23 mM)
You can also refer to dose conversion for different animals. 詳細
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Guanidinosuccinic acid 6133-30-8 Metabolism Others Endogenous Metabolite Inhibitor inhibit inhibitor