Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 36,000 |
5 mg | 在庫あり | ¥ 76,500 |
10 mg | お問い合わせ | ¥ 122,000 |
25 mg | お問い合わせ | ¥ 198,000 |
50 mg | お問い合わせ | ¥ 273,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 86,000 |
説明 | Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice. |
In vitro | Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass. |
In vivo | The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected. |
別名 | GR-7 |
分子量 | 495.64 |
分子式 | C25H41FNaO5S |
CAS No. | 2553218-46-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (489.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Gut restricted-7 2553218-46-3 Membrane transporter/Ion channel Potassium Channel acid Inhibitor GR-7 bile Bacterial orally Nontoxic Gut restricted 7 GR7 Gut restricted7 gut BSH gut-restricted inhibit GR 7 inhibitor