Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 16,000 | |||
500 mg | 在庫あり | ¥ 26,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
ターゲット&IC50 | ERβ:0.175 nM(EC50), ERα:0.07 nM(EC50) |
In vitro | Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6] |
In vivo | Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7] |
別名 | Bibenzyl, Hexanoestrol, meso-Hexestrol, Hexestrofen |
分子量 | 270.37 |
分子式 | C18H22O2 |
CAS No. | 84-16-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 39 mg/mL (144.2 mM)
Ethanol: 39 mg/mL (144.2 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Hexestrol 84-16-2 Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor Bibenzyl estrogen Hexanoestrol meso-Hexestrol Hexestrofen inhibit nonsteroidal Inhibitor synthetic inhibitor