|
T61444 |
Nonsteroidal aromatase inhibitor 1
|
|
|
|
Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for researc... |
|
T19823 |
Tebufenozide
|
|
Apoptosis
|
|
Tebufenozide is a novel nonsteroidal ecdysone agonist. It shows good efficacy and playing an increasingly important role in the control of Lepidopteran pests. |
|
T8575 |
ENFENAMIC ACID
|
|
Platelet aggregation
|
|
Enfenamic acid is a platelet aggregation inhibitor and with antirheumatic. |
|
T7436 |
Cilofexor
|
|
FXR
,
Autophagy
|
|
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. |
|
T0291 |
Flurbiprofen
|
dl-Flurbiprofen |
Apoptosis
,
COX
,
MRP
|
|
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. |
|
T12832 |
Amcenestrant
|
SAR439859 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
|
|
Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation). |
|
T28362 |
PF-02413873
|
PF02413873 |
Progesterone Receptor
|
|
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis. |
|
T4561 |
Tiaprofenic acid
|
Tiaprofensaeure,Acido tiaprofenico,Surgam |
Others
,
COX
|
|
Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain. |
|
T6533 |
Hexestrol
|
Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
|
|
Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
|
T36683 |
Vedaprofen
|
Quadrisol,PM 150,CERM 10202 |
COX
,
Antibacterial
,
Prostaglandin Receptor
|
|
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM. |
|
T0459 |
Sulindac
|
Arthrocine,MK-231,Clinoril,Sulindac sulfoxide |
COX
,
Autophagy
|
|
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... |
|
T21395 |
Finerenone
|
BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 |
Glucocorticoid Receptor
|
|
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... |
|
T13184 |
Topilutamide
|
Fluridil,BP766 |
Others
|
|
Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen. |
|
T0826 |
Meloxicam
|
Movalis,Mobic,Metacam |
Apoptosis
,
COX
,
Autophagy
|
|
Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds. |
|
T2550 |
Tolmetin
|
Tolectin |
COX
|
|
Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds. |
|
T1280 |
Nepafenac
|
AL 6515,AHR 9434 |
COX
|
|
Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds. |
|
T0708 |
Oxaprozin
|
Oxaprozinum,Wy21743 |
NF-κB
,
COX
|
|
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound... |
|
T28454 |
Proquazone
|
Proquazona,Arthrex,Proquazonum,Biarison |
Others
|
|
Proquazone (Arthrex) is a nonsteroidal anti-inflammatory agent. |
|
T6497 |
Fenoprofen Calcium
|
|
Others
,
COX
|
|
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. |
|
T25956 |
Piketoprofen
|
Calmatel |
Others
|
|
Piketoprofen (Calmatel) is a topical nonsteroidal anti-inflammatory agent. |
|
T20761 |
RU 59063
|
RU-59063,RU59063 |
Androgen Receptor
|
|
RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands. |
|
T7197 |
Fadrozole
|
|
Aromatase
|
|
Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM) |
|
T50025 |
Lonazolac
|
|
PPAR
|
|
Lonazolac is a nonsteroidal anti-inflammatory drug[1]. |
|
T19636 |
Morniflumate
|
Niflam,UP 164,UP-164,Morniflu,UP164 |
Others
|
|
Morniflumate (Niflam) is a nonsteroidal anti-inflammatory drug. It is used to treat inflammation. |
|
T67818 |
BMS-641988
|
|
Androgen Receptor
|
|
BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer. |
|
T0258 |
Carsalam
|
Carsalame,Carbonylsalicylamide,2H-1,3-Benzoxazine-2,4(3H)-dione |
Antibiotic
|
|
Carsalam (2H-1,3-Benzoxazine-2,4(3H)-dione) is a nonsteroidal anti-inflammatory drug. |
|
TQ0225 |
Velsecorat
|
AZD7594,AZ13189620 |
Glucocorticoid Receptor
|
|
Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM). |
|
T15364 |
G-1
|
|
Estrogen Receptor/ERR
,
GPR
|
|
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM). |
|
T22818 |
GSK9027
|
GR agonist 23a,GSK 9027,GSK-9027 |
Glucocorticoid Receptor
|
|
GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity. |
|
T0466 |
Celecoxib
|
SC 58635 |
COX
|
|
Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor. |
|
T23403 |
Sulindac sulfone
|
|
Reductase
,
COX
|
|
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. |
|
T1749 |
AL 082D06
|
D-06,AL082D06 |
Glucocorticoid Receptor
|
|
AL 082D06 (D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > 10 uM). |
|
T0726 |
Benzydamine hydrochloride
|
Benzydamine HCl,AF864 |
COX
,
PGE Synthase
,
Antibacterial
|
|
Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties. |
|
T27335 |
Floctafenine
|
RU 15750,R-4318,R 4318,RU-15750,R4318 |
COX
|
|
Floctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.Floctafenine has analgesic activity and is ... |
|
T15750 |
Ligandrol
|
LGD-4033 |
Androgen Receptor
|
|
Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity. |
|
T0380 |
Bicalutamide
|
ICI-176334 |
Androgen Receptor
,
Autophagy
|
|
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. |
|
T0035 |
Dienestrol
|
Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
|
|
Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy. |
|
T1325 |
Carprofen
|
Ridamyl,Imadyl,Rimadyl |
FAAH
,
COX
,
Autophagy
|
|
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. |
|
T27312 |
Fentiazac
|
Donorest,Flogene,BR-700 |
Others
|
|
Fentiazac（BR-700） is an orally active nonsteroidal alkanoic acid derivative with significant analgesic, anti-inflammatory, and antipyretic activity.Fentiazac is used in the study of inflammatory diseases such as rheumato... |
|
T14116 |
ACP-105
|
|
Androgen Receptor
|
|
ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. |
|
T22330 |
Fenamic acid
|
2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid |
Chloride channel
|
|
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... |
|
T26322 |
Vorozole
|
R83839,R 83839,R-83839,(+)-Vorozole,R83842 |
P450
,
Aromatase
|
|
Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer. |
|
T0432 |
Diclofenac diethylamine
|
|
Apoptosis
,
COX
|
|
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). |
|
T26537 |
AC-186
|
AC186,AC 186 |
Estrogen/progestogen Receptor
|
|
AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study o... |
|
T6424 |
Bromfenac Sodium
|
AHR 10282B,Bronuck,AHR 10282R |
COX
|
|
Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
|
T0458 |
Indomethacin
|
Indocin,Indometacine,Indomethacine,Indometacin |
Phospholipase
,
COX
,
PDE
,
Autophagy
|
|
Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor. |
|
T6470 |
Diclofenac Potassium
|
CGP-45840B,Cataflam,Voltfast |
Apoptosis
,
Others
,
COX
|
|
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
|
T7882 |
Indomethacin farnesil
|
Infree |
Others
,
COX
,
Autophagy
|
|
Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD). |
|
T0219 |
Valdecoxib
|
SC 65872 |
COX
|
|
Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or N... |
|
T1394 |
Ibuprofen
|
Brufen,(±)-Ibuprofe,Motrin,Advil |
COX
|
|
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... |
