Powder: -20°C for 3 years | In solvent: -80°C for 1 year
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
説明 | I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST. |
ターゲット&IC50 | Hippo pathway:2.7 μM |
In vitro | I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2]. |
別名 | HMPSNE |
分子量 | 310.37 |
分子式 | C17H14N2O2S |
CAS No. | 459420-09-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120mg/mL (386.64mM)
You can also refer to dose conversion for different animals. 詳細
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I3MT-3 459420-09-8 Stem Cells Hippo pathway EA.hy926 cells Hippo (MST) inhibit 3MST HEK293 I3MT3 cell-membrane HMPSNE COS-7 I-3MT-3 I3MT 3 Inhibitor inhibitor