Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
500 mg | 在庫あり | ¥ 590,000 |
説明 | IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes. |
ターゲット&IC50 | MST1:23 nM, MST2:652 nM, MST1:240 nM(kd) |
In vitro | IHMT-MST1-58 (0.1-10 μM; 1-2 h) inhibits the phosphorylation of MST1 in vitro.[1] IHMT-MST1-58 (0.03, 0.1 and 0.3 μM; 48 h) exhibits a significant protective effect of β cells from the damage caused by inflammatory cytokines.[1] |
In vivo | IHMT-MST1-58 (p.o, 50 mg/kg/day, QD) combined with metformin resulted in the reduction of fasting blood glucose, demonstrating the protective effect on β cells and decrease in hemoglobin A1c levels in the STZ-induced T1D/T2D mouse models.[1] |
分子量 | 438.5 |
分子式 | C21H22N6O3S |
CAS No. | 2414484-25-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1mg/ml, Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IHMT-MST1-58 2414484-25-4 Stem Cells Hippo pathway Inhibitor inhibitor inhibit