Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,000 | |||
5 mg | 在庫あり | ¥ 55,000 | |||
10 mg | 在庫あり | ¥ 87,000 | |||
25 mg | 在庫あり | ¥ 147,000 | |||
50 mg | 在庫あり | ¥ 209,500 | |||
100 mg | 在庫あり | ¥ 282,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 60,500 |
説明 | IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway. |
ターゲット&IC50 | SHP2:15.7 nM |
In vitro | IACS-13909 potently impeded proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver. |
In vivo | In EGFR-mutant osimertinib-resistant NSCLC models with EGFR-dependent and EGFR-independent resistance mechanisms, IACS-13909, administered as a single agent or in combination with osimertinib, potently suppressed tumor cell proliferation?in vitro?and caused tumor regression?in vivo. |
別名 | BBP-398 |
分子量 | 377.27 |
分子式 | C17H18Cl2N6 |
CAS No. | 2160546-07-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (23.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IACS-13909 2160546-07-4 Metabolism Phosphatase antiproliferative RTK BBP-398 inhibit IACS 13909 SHP2 pMEK anticancer Inhibitor MAPK BBP 398 BBP398 pERK IACS13909 inhibitor