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カタログ番号 | 製品名 | 別名 | ターゲット |
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T71944 | FGF/PDGF/VEGF RTK Inhibitor | ||
FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of h... | |||
T9196 | IACS-13909 | BBP-398 | Phosphatase |
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway. | |||
T14137 | AG 1295 | PDGFR | |
AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4]. | |||
T13176 | TNO155 | Batoprotafib | Phosphatase |
TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity. | |||
T6920 | ON123300 | FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK | |
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM). | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T6289 | Dovitinib | TKI258,CHIR-258 | VEGFR , FGFR , FLT , PDGFR , c-Kit |
Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E... | |||
T5467 | SAR125844 | SAR125884 | Apoptosis , c-Met/HGFR |
SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L) | |||
T1797 | Cabozantinib S-malate | Cabozantinib,XL184,Cabozantinib Malate | Apoptosis , VEGFR , c-Met/HGFR , TAM Receptor , c-Kit |
Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. | |||
T7394 | Toceranib Phosphate | SU11654 phosphate,PHA 291639 phosphate | VEGFR , Tyrosinase , PDGFR , c-Kit |
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR | |||
T0374L | Sunitinib | SU 11248 | Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy |
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga... | |||
T21723L | Epidermal Growth Factor Receptor Peptide Acetate | Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) | Others |
Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)) exists on the cell surface and is activated by the binding of its specific ligands.EGFR belongs t... | |||
T13178 | Toceranib | PHA 291639E,SU11654 | VEGFR , PDGFR , c-Kit |
T2115 | Pexidartinib | PLX-3397 | Apoptosis , c-Fms , FLT , CSF-1R , c-Kit |
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. | |||
T1773 | Afatinib Dimaleate | BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate | EGFR , HER , Autophagy |
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act... | |||
T6479 | Dovitinib lactate hydrate | Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258 | VEGFR , FGFR , FLT , PDGFR , c-Kit |
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R... | |||
T6082 | SSR128129E | SSR | FGFR |
SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs. | |||
T15616 | JNJ-10198409 | JNJ-10198409 | PDGFR |
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, ant... | |||
T5677 | SAR125884 hydrochlorid (1116743-46-4(free base)) | c-Met/HGFR | |
SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM). | |||
T73552 | BPDA2 | ||
BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively. This compound effectively downregulates mitogenic and ce... | |||
T36102 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | ||
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone dea... | |||
T72574 | Axl/Mer/CSF1R-IN-1 | ||
Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM. | |||
T63600 | EtDO-P4 | ||
EtDO-P4 is a nanomolar inhibitor of sphingolipid (GSL) synthesis. etDO-P4 inhibits EGFR-induced activation of the ERK pathway and various receptor tyrosine kinases (RTK). etDO-P4 can be used to study a variety of tumor t... | |||
T78694 | SHP2-IN-13 | ||
SHP2-IN-13 is an orally active, highly selective allosteric inhibitor targeting the SHP2 “tunnel site,” exhibiting an IC50 of 83.0 nM. It holds potential for research into cancers with RTK oncogenic drivers and diseases ... | |||
T6193 | Dovitinib Dilactic Acid | Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid | VEGFR , FGFR , FLT , c-Kit |
Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FG... | |||
T61872 | Trk-IN-10 | ||
Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 ... | |||
T12925 | Sitravatinib malate | MGCD516 malate,MG-516 malate | TAM Receptor |
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT... | |||
T62093 | Trk-IN-11 | ||
Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK, with IC50 values of 1.4 nM for TrkA and 1.8 nM for TrkA G595R. Trk-IN-11 has shown research potential in cancer diseases. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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Fr16741 | Oxindole | Indolin-2-one | Others , HIV Protease |
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases ... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01289 | DDR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1. | |||
TMPY-04382 | DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) | Human | Baculovirus Insect Cells |
DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 80 kDa and the accession number is Q08345-1. | |||
TMPK-00417 | MERTK/Mer Protein, Human, Recombinant (His) | Human | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu... | |||
TMPK-00418 | MERTK/Mer Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu... | |||
TMPJ-01143 | MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) | Human | HEK293 Cells |
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one... | |||
TMPK-01022 | MERTK/Mer Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu... | |||
TMPK-00979 | EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) | Cynomolgus | HEK293 Cells |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; t... | |||
TMPK-00980 | EPhA2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; t... | |||
TMPJ-00424 | EphB2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Ephrin type-B receptor 2(EPHB2) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHB2 contains 1 Eph LBD domain, 2 fibronectin type-III domains, 1 protein kinase domain and 1 SAM domain. Ephrin r... |