Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 80,000 | |||
100 mg | 在庫あり | ¥ 123,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.) |
ターゲット&IC50 | PI3Kγ:2.62 μM |
In vitro | IITZ-01 enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).?IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells. |
分子量 | 482.51 |
分子式 | C26H23FN8O |
CAS No. | 1807988-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (310.87 mM)
You can also refer to dose conversion for different animals. 詳細
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IITZ-01 1807988-47-1 Apoptosis Autophagy PI3K/Akt/mTOR signaling PI3K IITZ01 Phosphoinositide 3-kinase IITZ 01 inhibit Inhibitor inhibitor