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Search Results for " Notch "

ターゲット

46

阻害剤

7

天然化合物

38

リコンビナントタンパク質

4

ライブラリー

カタログ番号 製品名 別名 ターゲット
T16341 Notch inhibitor 1 Others
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.
T19483 Notch 1 TFA Others
Notch 1 TFA encodes a member of the NOTCH family of proteins.
T3540 IMR-1A Gamma-secretase , Drug Metabolite
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T12246 CB-103 Gamma-secretase
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T6861 IMR-1 Gamma-secretase
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T3075 FLI-06 FLI 06 Gamma-secretase
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
T6063 LY-411575 LY411575 Apoptosis , Gamma-secretase
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
T6249 Avagacestat BMS-708163 Gamma-secretase
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T6202 DAPT LY-374973,GSI-IX Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
T6274 RO4929097 RG-4733 Beta Amyloid , Gamma-secretase
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T6125 Semagacestat LY450139 Beta Amyloid , Gamma-secretase
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T13410 ZLDI-8 Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid Compound W Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T6935 Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014 Apoptosis , Gamma-secretase
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
T6135 YO-01027 gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ Gamma-secretase
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
T1602 Valproic acid sodium salt Sodium Valproate Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T6474 Divalproex Sodium Valproate semisodium,Epival HDAC
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...
TP1540 Jagged-1 (188-204) Jagged-1 188-204 Gamma-secretase
Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay...
T3521 γ-Secretase-IN-1 Compound E Beta Amyloid , Gamma-secretase
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
T14680 BMS-906024 Osugacestat,AL-101,BM-0018 Gamma-secretase
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-...
T31987 Gossypolone Wnt/beta-catenin , Gamma-secretase
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
T9015 LY900009 Gamma-secretase
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
T35566 RBPJ Inhibitor-1 RIN1 Gamma-secretase
RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1].
T21890 JLK6 Gamma-secretase
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
T76788 Demcizumab OMP 21M18 Gamma-secretase
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, both alone and in combination with chemotherapy agents.
T11718 JI051 JI-051 Gamma-secretase
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inh...
T24159 IHR-1 IHR 1 Smo
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
TP1293 Jagged-1 (188-204) TFA(219127-21-6 free base) Jagged-1 (188-204) TFA Gamma-secretase
Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing sub...
T12277 NVS-ZP7-4 Others
NVS-ZP7-4 is a inhibitor of Zinc transporter SLC39A7 (ZIP7).
T2003 ISX-9 Isoxazole 9,Isoxazole 9 (ISX-9) Calcium Channel , Wnt/beta-catenin
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
T6870 L-685458 L-685,458 Apoptosis , Gamma-secretase
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T15184 E 2012 Gamma-secretase
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc...
TP2117 SAHM1
Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.
T14683 BMS-983970 Gamma-secretase
T24210 JNJ-40418677
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.
T35546 Yhhu 3792
Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes...
T76054 SAHM1 TFA
SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assemb...
T13917 TCFA15 Others
tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.
T17281 Z-Ile-Leu-aldehyde Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII Others
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.
T76023 Jagged-1 (188-204) (TFA)
Jagged-1 (188-204) TFA, a fragment of the Jagged-1 (JAG-1) protein, acts as a Notch agonist. This compound is significantly present in both cultured and primary multiple myeloma (MM) cells, where JAG-1 facilitates the ma...
T12634 (R)-NVS-ZP7-4 Others
(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as...
T73485 BT-GSI
BT-GSI, a γ-secretase inhibitor (GSI) with bone-targeting capabilities, effectively inhibits Notch signaling. Exhibiting dual action, it possesses both anti-myeloma and anti-resorptive properties, making it a promising c...
T61930 Yhhu-3792
Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 enhanced the self-renewal ability of neural stem cells (NSCs), expanded the NSC pool and promoted endogenous neurogenesi...
T68980 MRK003
MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM a...
T80615 Enoticumab REGN421
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody that specifically targets human Delta-like ligand 4 (Dll4), which serves as a crucial component of the Notch signaling pathway and regulates the uptake of fatty acids ...

Compounds

Notch inhibitor 1
T16341
Synonym:
Target: Others
Notch 1 TFA
T19483
Synonym:
Target: Others
IMR-1A
T3540
Synonym:
Target: Gamma-secretase, Drug Metabolite
CB-103
T12246
Synonym:
Target: Gamma-secretase
IMR-1
T6861
Synonym:
Target: Gamma-secretase
FLI-06
T3075
Synonym: FLI 06
Target: Gamma-secretase
LY-411575
T6063
Synonym: LY411575
Target: Apoptosis, Gamma-secretase
Avagacestat
T6249
Synonym: BMS-708163
Target: Gamma-secretase
Crenigacestat
T3633
Synonym: LY3039478
Target: Gamma-secretase
DAPT
T6202
Synonym: LY-374973,GSI-IX
Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy
RO4929097
T6274
Synonym: RG-4733
Target: Beta Amyloid, Gamma-secretase
Semagacestat
T6125
Synonym: LY450139
Target: Beta Amyloid, Gamma-secretase
ZLDI-8
T13410
Synonym:
Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related
3,5-Bis(4-nitrophenoxy)benzoic acid
T22678
Synonym: Compound W
Target: Gamma-secretase
Nirogacestat
T6935
Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014
Target: Apoptosis, Gamma-secretase
YO-01027
T6135
Synonym: gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ
Target: Gamma-secretase
Valproic acid sodium salt
T1602
Synonym: Sodium Valproate
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy
Divalproex Sodium
T6474
Synonym: Valproate semisodium,Epival
Target: HDAC
Jagged-1 (188-204)
TP1540
Synonym: Jagged-1 188-204
Target: Gamma-secretase
γ-Secretase-IN-1
T3521
Synonym: Compound E
Target: Beta Amyloid, Gamma-secretase
BMS-906024
T14680
Synonym: Osugacestat,AL-101,BM-0018
Target: Gamma-secretase
Gossypolone
T31987
Synonym:
Target: Wnt/beta-catenin, Gamma-secretase
LY900009
T9015
Synonym:
Target: Gamma-secretase
RBPJ Inhibitor-1
T35566
Synonym: RIN1
Target: Gamma-secretase
JLK6
T21890
Synonym:
Target: Gamma-secretase
Demcizumab
T76788
Synonym: OMP 21M18
Target: Gamma-secretase
JI051
T11718
Synonym: JI-051
Target: Gamma-secretase
IHR-1
T24159
Synonym: IHR 1
Target: Smo
Jagged-1 (188-204) TFA(219127-21-6 free base)
TP1293
Synonym: Jagged-1 (188-204) TFA
Target: Gamma-secretase
NVS-ZP7-4
T12277
Synonym:
Target: Others
ISX-9
T2003
Synonym: Isoxazole 9,Isoxazole 9 (ISX-9)
Target: Calcium Channel, Wnt/beta-catenin
L-685458
T6870
Synonym: L-685,458
Target: Apoptosis, Gamma-secretase
E 2012
T15184
Synonym:
Target: Gamma-secretase
SAHM1
TP2117
Synonym:
Target:
BMS-983970
T14683
Synonym:
Target: Gamma-secretase
JNJ-40418677
T24210
Synonym:
Target:
Yhhu 3792
T35546
Synonym:
Target:
SAHM1 TFA
T76054
Synonym:
Target:
tCFA15
T13917
Synonym:
Target: Others
Z-Ile-Leu-aldehyde
T17281
Synonym: Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII
Target: Others
Jagged-1 (188-204) (TFA)
T76023
Synonym:
Target:
(R)-NVS-ZP7-4
T12634
Synonym:
Target: Others
BT-GSI
T73485
Synonym:
Target:
Yhhu-3792
T61930
Synonym:
Target:
MRK003
T68980
Synonym:
Target:
Enoticumab
T80615
Synonym: REGN421
Target:
カタログ番号 製品名 別名 ターゲット
TWS2045 Bruceine D Apoptosis , Antiviral , Gamma-secretase , Parasite
1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW...
T3399 Psoralidin Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T4S1990 Carvacrol Karvakrol,O-Thymol,cymophenol Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami...
T2842 Tangeretin NSC53909,Tangeritin,NSC618905 Apoptosis , Gamma-secretase
Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc...
T7064 Valproic Acid Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T7982 3,6-Dihydroxyflavone Others
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.
T3426 Bacoside A MMP , Others , TNF , Dopamine Receptor , NOS , ROS
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-05054 Notch 4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is i...
TMPY-05081 Notch 1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Notch 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.7 kDa and the accession number is P46531.
TMPK-01396 Notch 3 Protein, Human, Recombinant (His) Human HEK293 Cells
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular dom...
TMPK-01367 Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47.
TMPK-01374 Notch 3 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Notch 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 71.53 kDa and the accession number is Q9UM47.
TMPK-01360 Notch 3 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Notch 3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47.
TMPY-04930 Notch 2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPK-00868 Notch 4 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression ...
TMPY-02663 Notch 1 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
Notch 1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q01705-1.
TMPJ-01452 Notch 1 Protein, Mouse, Recombinant (aa 18-526, His) Mouse HEK293 Cells
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531...
TMPY-00415 Notch 1 Protein, Mouse, Recombinant (hFc) Mouse CHO Cells
Notch 1 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 80.6 kDa and the accession number is Q01705-1.
TMPK-00465 Notch 2 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of ...
TMPK-00467 Notch 1 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Notch 1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 56.5 kDa and the accession number is P46531.
TMPK-00466 Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of ...
TMPK-00468 Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 56.5 kDa and the accession number is P46531.
TMPY-05028 NOTCH2NL Protein, Human, Recombinant (mFc) Human HEK293 Cells
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH fa...
TMPK-00360 DLL4 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell pro...
TMPH-01783 NOTCH2NLB Protein, Human, Recombinant (His & Myc) Human Baculovirus Insect Cells
NOTCH2NLB Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 31.3 kDa and the accession number is P0DPK3.
TMPH-01784 NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.9 kDa and the accession number is P0DPK3.
TMPH-02854 Jagged 1 Protein, Mouse, Recombinant (His & Myc & SUMO) Mouse E. coli
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular...
TMPK-01083 ASPH Protein, Mouse, Recombinant (His) Mouse E. coli
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se...
TMPK-00945 ASPH Protein, Human, Recombinant (His) Human E. coli
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se...
TMPY-03276 BLBP Protein, Human, Recombinant Human E. coli
BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic l...
TMPY-03308 ADAM17 Protein, Rat, Recombinant (His) Rat HEK293 Cells
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative coliti...
TMPH-01654 MAGEA1 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal developmen...
TMPK-01030 LRRN1 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction be...
TMPK-01209 DLL3 Protein, Human, Recombinant (His) Human HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-00748 DLL3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-00543 DLL3 Protein, Cynomolgus, Recombinant (aa 27-477, His) Cynomolgus HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPH-02316 YJEFN3 Protein, Human, Recombinant Human E. coli
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endotheli...
TMPK-01210 DLL3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-01206 DLL3 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-00640 DLL3 Protein, Rhesus macaque, Recombinant (His) Rhesus HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-01207 DLL3 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-01208 DLL3 Protein, Human, Recombinant (His & Flag) Human HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPK-00542 DLL3 Protein, Cynomolgus, Recombinant (aa 27-488, His) Cynomolgus HEK293 Cells
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe...
TMPJ-01177 NOV/CCN3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor...
TMPH-02217 SMARCA4 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti...
Notch 4 Protein, Human, Recombinant (His)
TMPY-05054
Species: Human
Expression System: Baculovirus Insect Cells
Notch 1 Protein, Human, Recombinant (hFc)
TMPY-05081
Species: Human
Expression System: HEK293 Cells
Notch 3 Protein, Human, Recombinant (His)
TMPK-01396
Species: Human
Expression System: HEK293 Cells
Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01367
Species: Human
Expression System: HEK293 Cells
Notch 3 Protein, Human, Recombinant (hFc)
TMPK-01374
Species: Human
Expression System: HEK293 Cells
Notch 3 Protein, Human, Recombinant (His & Avi)
TMPK-01360
Species: Human
Expression System: HEK293 Cells
Notch 2 Protein, Human, Recombinant (His)
TMPY-04930
Species: Human
Expression System: Baculovirus Insect Cells
Notch 4 Protein, Mouse, Recombinant (His)
TMPK-00868
Species: Mouse
Expression System: HEK293 Cells
Notch 1 Protein, Mouse, Recombinant (His)
TMPY-02663
Species: Mouse
Expression System: Baculovirus Insect Cells
Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)
TMPJ-01452
Species: Mouse
Expression System: HEK293 Cells
Notch 1 Protein, Mouse, Recombinant (hFc)
TMPY-00415
Species: Mouse
Expression System: CHO Cells
Notch 2 Protein, Human, Recombinant (His & Avi)
TMPK-00465
Species: Human
Expression System: HEK293 Cells
Notch 1 Protein, Human, Recombinant (His & Avi)
TMPK-00467
Species: Human
Expression System: HEK293 Cells
Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00466
Species: Human
Expression System: HEK293 Cells
Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00468
Species: Human
Expression System: HEK293 Cells
NOTCH2NL Protein, Human, Recombinant (mFc)
TMPY-05028
Species: Human
Expression System: HEK293 Cells
DLL4 Protein, Human, Recombinant (His & Avi)
TMPK-00360
Species: Human
Expression System: HEK293 Cells
NOTCH2NLB Protein, Human, Recombinant (His & Myc)
TMPH-01783
Species: Human
Expression System: Baculovirus Insect Cells
NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01784
Species: Human
Expression System: E. coli
Jagged 1 Protein, Mouse, Recombinant (His & Myc & SUMO)
TMPH-02854
Species: Mouse
Expression System: E. coli
ASPH Protein, Mouse, Recombinant (His)
TMPK-01083
Species: Mouse
Expression System: E. coli
ASPH Protein, Human, Recombinant (His)
TMPK-00945
Species: Human
Expression System: E. coli
BLBP Protein, Human, Recombinant
TMPY-03276
Species: Human
Expression System: E. coli
ADAM17 Protein, Rat, Recombinant (His)
TMPY-03308
Species: Rat
Expression System: HEK293 Cells
MAGEA1 Protein, Human, Recombinant (His)
TMPH-01654
Species: Human
Expression System: P. pastoris (Yeast)
LRRN1 Protein, Mouse, Recombinant (His)
TMPK-01030
Species: Mouse
Expression System: HEK293 Cells
DLL3 Protein, Human, Recombinant (His)
TMPK-01209
Species: Human
Expression System: HEK293 Cells
DLL3 Protein, Mouse, Recombinant (His)
TMPK-00748
Species: Mouse
Expression System: HEK293 Cells
DLL3 Protein, Cynomolgus, Recombinant (aa 27-477, His)
TMPK-00543
Species: Cynomolgus
Expression System: HEK293 Cells
YJEFN3 Protein, Human, Recombinant
TMPH-02316
Species: Human
Expression System: E. coli
DLL3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-01210
Species: Human
Expression System: HEK293 Cells
DLL3 Protein, Human, Recombinant (His & Avi)
TMPK-01206
Species: Human
Expression System: HEK293 Cells
DLL3 Protein, Rhesus macaque, Recombinant (His)
TMPK-00640
Species: Rhesus
Expression System: HEK293 Cells
DLL3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01207
Species: Human
Expression System: HEK293 Cells
DLL3 Protein, Human, Recombinant (His & Flag)
TMPK-01208
Species: Human
Expression System: HEK293 Cells
DLL3 Protein, Cynomolgus, Recombinant (aa 27-488, His)
TMPK-00542
Species: Cynomolgus
Expression System: HEK293 Cells
NOV/CCN3 Protein, Mouse, Recombinant (His)
TMPJ-01177
Species: Mouse
Expression System: HEK293 Cells
SMARCA4 Protein, Human, Recombinant (His)
TMPH-02217
Species: Human
Expression System: P. pastoris (Yeast)
カタログ番号 製品名
L4300 Wnt/Hedgehog/Notch Compound Library

237 compounds
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L2600 Neuronal Signaling Compound Library

2540 compounds
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L7900 Osteogenesis Compound Library

317 compounds
A unique collection of 317 osteogenesis related compounds for high throughput and high content screening;
L7700 Neural Regeneration Compound Library

524 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;