Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 14,500 | |||
25 mg | 在庫あり | ¥ 27,000 | |||
50 mg | 在庫あり | ¥ 45,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM). |
ターゲット&IC50 | Porcn:0.5 nM(EC50) |
In vitro | In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions. |
In vivo | In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells. |
別名 | Porcn Inhibitor III, IWP-L6, Porcn Inhibitor III |
分子量 | 472.58 |
分子式 | C25H20N4O2S2 |
CAS No. | 1427782-89-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 47.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IWP L6 1427782-89-5 Stem Cells Porcupine IWP L 6 inhibit Porcn Inhibitor III IWP-L6 Inhibitor IWP L-6 Porcn?Inhibitor?III Porcn Inhibitor III inhibitor