Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
説明 | IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. |
ターゲット&IC50 | Porcn:80 pM (EC50, in L-Wnt-STF cells) |
In vitro | IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM. |
分子量 | 432.48 |
分子式 | C26H20N6O |
CAS No. | 2074607-48-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (138.73 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IWP-O1 2074607-48-8 Cytoskeletal Signaling Stem Cells Porcupine Wnt/beta-catenin Wnt IWP-O-1 IWPO1 inhibit Inhibitor IWP O1 inhibitor