Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 12,000 | |||
25 mg | 在庫あり | ¥ 25,000 | |||
50 mg | 在庫あり | ¥ 41,000 | |||
100 mg | 在庫あり | ¥ 66,500 | |||
200 mg | 在庫あり | ¥ 98,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. |
In vitro | Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein[1]. |
In vivo | In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged[1]. |
別名 | Sephin 1, lcerguastat, IFB-088 |
分子量 | 196.64 |
分子式 | C8H9ClN4 |
CAS No. | 951441-04-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL(1017.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Icerguastat 951441-04-6 Metabolism Phosphatase Sephin1 Inhibitor IFB088 misfolding Sephin-1 prion IFB 088 stress eIF2α sclerosis Sephin 1 inhibit lcerguastat IFB-088 protein inhibitor