Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
説明 | Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
ターゲット&IC50 | P2X1:2.40μM , P2X3:3.49 μM , P2X4:2.71μM |
In vitro | Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7. |
分子量 | 523.75 |
分子式 | C19H15BrClF3N2O3S |
CAS No. | 1207660-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (47.73 mM)
You can also refer to dose conversion for different animals. 詳細
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Indophagolin 1207660-00-1 Autophagy GPCR/G Protein Membrane transporter/Ion channel Neuroscience P2X Receptor 5-HT Receptor inhibit formation Inhibitor 5-hydroxytryptamine Receptor autophagosome Serotonin Receptor P2XRs membrane-bound indoline-based class inhibitor