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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9000 | Pyrimorph | Antifungal | |
Pyrimorph is a fungicide with high activity against the plant pathogen Phytophthora capsici. Pyrimorph inhibited different stages in the life cycle of P. capsici including mycelial growth, sporangium production, zoospore... | |||
T7692 | 2,4-DPD | HIF | |
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH) | |||
T22702 | CYM 50769 | Neuropeptide W | |
CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-ta... | |||
T6904 | Necrosulfonamide | (E)-Necrosulfonamide | MLK |
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec... | |||
T9107 | NP-G2-044 | Others | |
NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response. | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
T22089 | HPI 1 | Hedgehog/Smoothened | |
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... | |||
T8946 | Indophagolin | P2X Receptor , 5-HT Receptor , Autophagy | |
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. | |||
T16159 | Muramyl dipeptide | MDP | NOD |
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation... | |||
T9054 | RO6889678 | HBV | |
RO6889678 is HBV inhibitor with a complex ADME profile. | |||
T1893 | Parmodulin 2 | ML 161 | Protease-activated Receptor |
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb... | |||
T7566 | GRGDSPK | EMD 56574 | Others |
GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules. | |||
T28817 | SM4 | SM-4,SM 4 | Others |
SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo. | |||
T22119 | NS3694 | Apoptosis | |
NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation. | |||
T14075 | A-802715 | IL Receptor | |
A-802715 is a novel methylxanthine derivative that decreases the endogenous formation and blood levels of pro-inflammatory substances and increases the formation and blood levels of anti-inflammatory substances such as i... | |||
T9824 | WAY-325371 | Others | |
WAY-325371 can inhibit the formation of osteoclasts. | |||
T77506 | 1-vinylpyrene | 1-Ethenylpyrene | Others |
1-vinylpyrene (1-Ethenylpyrene) has antitumor activity and strongly inhibits the formation of skin tumors triggered by DMBA or B[]P in a dose-dependent manner and can be used to prevent tumor formation. | |||
T16280 | Nedocromil | FPL 59002 | Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor |
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). | |||
T29038 | KL8604166 | UCB11056,UCB-11056,UCB 11056 | Others |
Trometamol (UCB-11056) is a potential puzzle compound.UCB-11056 amplifies the formation of inducible cyclic AMP in rat brain tissue. | |||
T12094 | Monobehenin | Others , Antibacterial | |
Monobehenin has a strong inhibitory effect on the formation of bacterial biofilm. | |||
T5628 | P-cumylphenol | Others | |
p-cumylphenol can treat R enal Tubular Cyst Formation in Newborn Rats. | |||
T2186 | Tris(2,2,2-trifluoroethyl) borate | SL 75212 | Others |
Tris(2,2,2-trifluoroethyl) borate (SL 75212) is mostly used in condensation reactions. It has been shown to promote the direct formation of amides from carboxylic acids and amines as well as the formation of imines from ... | |||
TP1427L | ReACp53 acetate | p53 | |
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines. | |||
T1002 | Etodolac | Ultradol,AY-24236,Etodolic acid,Lodine | Retinoid Receptor , COX |
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic ... | |||
T22246 | Argatroban Monohydrate | Thrombin | |
Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. | |||
T35941 | DC-Chol hydrochloride | Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate | Beta Amyloid |
DC-Chol hydrochloride(DC-Cholesterol hydrochloride) inhibited the formation of Aβ40 fibrils under appropriate experimental conditions and significantly inhibited amyloid formation from oxidized hCT in a dose-dependent ma... | |||
T10723 | CDC25B-IN-1 | ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate | Phosphatase |
CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation. | |||
T9823 | WAY-325398 | Others | |
WAY-325398 is a furan derivatives. WAY-325398 inhibits osteoclast formation, inhibition rate is 14.11% at 10 μM. | |||
T0155 | Argatroban | MCI-9038,MD-805,Argipidine | Thrombin |
T68155 | Tebufelone | Prostaglandin Receptor , LTR | |
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul... | |||
T22595 | B2 | Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline | Others , Sirtuin |
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease | |||
T26408 | A 21960 | Ethyl 2-chloroacetoacetate,A21960,A-21960 | |
A 21960 (Ethyl 2-chloroacetoacetate) inhibits synapse formation between resolvase and two directly repeated res sites, blocks site-specific recombination reactions, and can be used to study bacterial infections. | |||
T80667 | 2-Methyl-1-Pyrroline | Others | |
2-Methyl-1-Pyrroline (2-MPN) is an intermediate of a photochemical dye that induces the formation of (R)-2-MP. | |||
T20511 | 6-Thioguanosine | 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422 | Others |
6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double ... | |||
T4172 | Methoxy-PMS | 1-Methoxyphenazine methosulfate,1-Methoxy PMS | Reactive Oxygen Species |
Methoxy-PMS (1-Methoxyphenazine methosulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes, can induce active oxygen formation. | |||
T7566L1 | GRGDSPK acetate | GRGDSPK acetate(111119-28-9 Free base) | Beta Amyloid |
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption. | |||
T60390 | PI-55 | 6-(2-hydroxy-3-methylbenzylamino)purine | Others |
PI-55 (6-(2-hydroxy-3-methylbenzylamino)purine) is a cytokinin receptor inhibitor that exhibits structural similarity to 6-benzylaminopurine (BAP). It competitively inhibits BAP binding on the specific Arabidopsis recept... | |||
T27084 | Crisdesalazine | AAD2004,AAD 2004,AAD-2004 | Prostaglandin Receptor |
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre... | |||
T10936 | D-I03 | DI03 | DNA/RNA Synthesis |
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 of 5 µM and 8 µM, respectively. D-I03 inhibited the grow... | |||
T0839 | Ketoprofen | RP-19583 | Apoptosis , COX , MRP |
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... | |||
T0157 | Roxatidine Acetate hydrochloride | HOE 760,Roxatidine Acetate HCl | Histamine Receptor |
Roxatidine Acetate hydrochloride (HOE 760) is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation. | |||
T13171 | TMN355 | Others | |
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. | |||
T0389 | Dabigatran etexilate | BIBR 1048 | Thrombin |
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. | |||
T36696 | DMBA | ||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... | |||
T9108 | BI-0115 | Lipoxygenase | |
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX... | |||
T31206 | Darexaban | YM 150,Darexaban, Tanexaban,YM150 | Factor Xa |
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... | |||
T2238 | Cariporide | HOE-642 | Sodium Channel |
Cariporide (HOE-642) (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (... | |||
T77695 | Muvalaplin | LY3473329 | Others |
Muvalaplin (LY3473329) is an orally active lipoprotein (a) Lp(a) reagent that inhibits Lp(a) formation by blocking apo(a)-apo B100 interactions. | |||
T40661 | ML-60218 | DNA/RNA Synthesis | |
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms. | |||
T15756 | Lidorestat | IDD-676 | Reductase |
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13509 | 4-Vinylphenol | Apoptosis , Endogenous Metabolite | |
T2731 | Usnic Acid | Usniacin | Antibacterial , Autophagy |
Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells. | |||
TN6848 | Piperonylic acid | 2H-1,3-benzodioxole-5-carboxylic acid | P450 |
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73... | |||
T8846 | Beta-Escin | B-escin,AESCINE | Immunology/Inflammation related |
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. | |||
T2819 | Methyl p-coumarate | Methyl 4-hydroxycinnamate | Others , Antifungal |
"Methyl 4-hydroxycinnamate is an esterified derivative of p-coumaric acid isolated from the flowers of Trixis michuacana var. longifolia, exhibiting antibacterial and anti-melanogenesis properties." | |||
TN1043 | Keracyanin chloride | Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride | COX |
Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin compound, exhibits antioxidant properties. It effectively prevents the formation of malonaldehyde in oxidized calf thymus DNA, underlining its potentia... | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
T20597 | Alginic acid | Protanal LF,Snow acid algin G,Kelacid,Sazzio,Norgine | Apoptosis , Autophagy , Histamine Receptor |
Alginic acid (Snow acid algin G) is a natural polysaccharide extracted from brown seaweeds with anti-anaphylactic and anti-inflammatory activities. Alginic acid inhibits histamine release and can be used in the food indu... | |||
T4890 | 3-Nitro-L-tyrosine | 3-Nitrotyrosine | Endogenous Metabolite |
3-Nitro-L-tyrosine (3-Nitrotyrosine) is the major product from the spontaneous reaction of peroxynitrite with tyrosine. Formation of nitrotyrosine can indicate the formation of peroxynitrite by a nitric oxide (NO)-depend... | |||
T7097 | Cytochalasin B | Phomin | Arp2/3 Complex |
T10048 | 17a-Hydroxypregnenolone | Endogenous Metabolite | |
17a-Hydroxypregnenolone is a pregnane steroid. It is a prohormone in the formation of dehydroepiandrosterone (DHEA). | |||
TN2122 | Quercetin 3-gentiobioside | Quercetin-3-gentiobioside | Reductase |
Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and... | |||
T26366 | Dehydroepiandrosterone sulfate | PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005 | Others |
Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses. | |||
T5S1261 | Methylophiopogonanone B | Ras | |
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation. | |||
T10183 | 6-Methoxytricin | Others | |
6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ... | |||
T5985 | Glycolic acid | Tyrosinase , Endogenous Metabolite | |
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products | |||
T0810 | Ethambutol dihydrochloride | Ethambutol 2HCl,Emb dihydrochloride,CL40881 | Antibacterial , Antibiotic , Antifungal |
Ethambutol dihydrochloride (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. | |||
T19288 | DL-Arginine | Others | |
DL-Arginine is deployed in the study of amino acid complexation dynamics and the formation of crystal structures. | |||
T7773 | DPPC | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL,129Y83 | Endogenous Metabolite |
DPPC (129Y83) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes. | |||
T1668 | Vinblastine sulfate | NSC49842,Vincaleukoblastine sulfate salt | Microtubule Associated , AChR , Autophagy |
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM). | |||
T4738 | Sodium 2-hydroxybutanoate | 2-Hydroxybutyric acid sodium salt,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE | Others , Endogenous Metabolite |
Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH... | |||
TN2151 | Rhamnocitrin | Others | |
Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune. | |||
T67731 | Holomycin | N-Demethylthiolutin | DNA/RNA Synthesis |
Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753... | |||
T6S2116 | Ginkgolic acid C17:1 | Phosphatase , PTEN | |
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T2S1086 | Nepitrin | Nepetin-7-glucoside | Antioxidant |
1. Nepitrin (Nepetin-7-glucoside) has antioxidant activity in human HL6 cells assessed as reduction of cytochrome-c release, DPPH free radical scavenging activity, and inhibition of TPA-induced free radical formation. | |||
T8073 | Disodium succinate | Sodium succinate | Others |
Disodium succinate (Sodium succinate) is the sodium salt form of succinate, which is an important metabolite at the cross-road of several metabolic pathways and involved in the formation and elimination of reactive oxyge... | |||
T1695 | DL-O-Tyrosine | Amino Acids and Derivatives | |
DL-o-Tyrosine is a metabolite of Phenylalanine and is a precursor in the formation of catecholamines. It is used as biomarkers of protein oxidative damage in β-thalassemia. | |||
TN1471 | Cassiaside C | Toralactone 9-O-β-D-gentiobioside | Others , Endogenous Metabolite |
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE). | |||
T5081 | Adenine monohydrochloride hemihydrate | Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate | Endogenous Metabolite , Adenosine Receptor |
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a... | |||
T2964 | 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside | 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols | Others |
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, inhibits the formation of 5-HETE, HHT and thromboxane B2. | |||
T1270 | Vincristine sulfate | Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate | Apoptosis , Microtubule Associated |
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle. | |||
TN3460 | Asebogenin | Antifungal | |
Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli. | |||
T4898 | Potassium 1-carboxyvinyl hydrogenphosphate | PEP-K,Phospho(enol)pyruvic acid monopotassium | Others , Endogenous Metabolite |
Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of arom... | |||
T2759 | Loganin | Loganoside | Apoptosis , NF-κB , BACE , AChR , AChE |
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor... | |||
T0019 | Betaine chloride | Betaine hydrochloride | Others , Chloride channel , Endogenous Metabolite |
Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the formation of secondary structure in GC-... | |||
T0190 | Vinorelbine | KW-2307 base | Microtubule Associated |
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. | |||
T1630 | Tiopronin | Thiopronine,Acadione,Captimer | ROS |
Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. | |||
TMS2182 | Trans-Zeatinriboside | Ribosylzeatin,Zeatin Riboside,Trans-Zeatin Riboside | Others |
trans-Zeatinriboside (Ribosylzeatin) is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process,... | |||
T14291 | Anisindione | Others | |
Anisindione is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibi... | |||
T64911 | Blasticidin S HCl | Antibiotic | |
Blasticidin S HCl is a peptide-based nucleoside antibiotic (antibiotic) isolated from Streptomyces griseochromogenes that inhibits prokaryotic and eukaryotic protein synthesis by interfering with the formation of peptide... | |||
TN2269 | Tetramethylcurcumin | Apoptosis , STAT | |
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e... | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T3S1729 | Dihydrolycorine | Others | |
1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inh... | |||
TN7246 | 3-Sulfopropanoic acid | 3-SPA | Drug Metabolite |
3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers. | |||
T5288 | Cytidine-5'-triphosphate disodium | CTP,Cytidine 5'-triphosphate (disodium salt) | Others , Endogenous Metabolite |
Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases... | |||
TN2286 | Tsugaric acid A | NO Synthase | |
Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t... | |||
T3S0218 | Thonningianin A | Apoptosis , Others | |
1. Thonningianin A has anti-cancer activities.2. Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor.3. Thonningianin A has antioxidant property, involves radical scavenging, anti-superox... | |||
TN2347 | Methylsticin | Methysticin | Others |
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu... | |||
T0928 | L-Ascorbic acid | Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate | Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite |
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-05822 | Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His) | HBV-D | E. coli |
Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of ... | |||
TMPY-03523 | ANGPTL4 Protein, Human, Recombinant (His) | Human | HEK293 |
ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancrea... | |||
TMPH-02151 | OXCT1 Protein, Human, Recombinant (His) | Human | E. coli |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of... | |||
TMPY-01633 | SOST Protein, Rat, Recombinant (His) | Rat | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-00925 | SOST Protein, Human, Recombinant (His) | Human | HEK293 |
Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and prima... | |||
TMPY-01009 | TGFBI Protein, Human, Recombinant (His) | Human | HEK293 |
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ... | |||
TMPY-05423 | C-MPL Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number o... | |||
TMPY-00890 | Noggin/NOG Protein, Human, Recombinant (hFc) | Human | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPH-00010 | MMP-14 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tiss... | |||
TMPY-02594 | Noggin/NOG Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-05202 | Noggin/NOG Protein, Human, Recombinant | Human | HEK293 |
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathw... | |||
TMPY-00118 | MCP-1/CCL2 Protein, Human, Recombinant (His) | Human | Yeast |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit ... | |||
TMPY-03441 | SAE1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL... | |||
TMPJ-00254 | TGF beta 3 Protein, Human/Mouse/Rat, Recombinant | Human,Mouse,Rat | Human Cells |
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti... | |||
TMPY-00680 | BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc) | Human,Mouse,Rat,Rhesus,Canine | HEK293 |
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokin... | |||
TMPJ-00842 | FGF-2 Protein, Rat, Recombinant | Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ... | |||
TMPK-00474 | IL-22RA1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o... | |||
TMPY-02185 | Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) | Human | HEK293 |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ... | |||
TMPY-03364 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-02726 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-03674 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-04811 | DKK1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-01174 | DKK1 Protein, Rhesus, Recombinant (N256Q, His) | Rhesus | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-00775 | DKK1 Protein, Human, Recombinant (His) | Human | HEK293 |
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 ... | |||
TMPY-00803 | Fibronectin Protein, Human, Recombinant (aa 607-1265, His) | Human | HEK293 |
Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet ... | |||
TMPY-00132 | Mesothelin Protein, Human, Recombinant | Human | HEK293 |
The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glyc... | |||
TMPJ-01465 | GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) | Human | E.coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of... | |||
TMPJ-00327 | M-CSF/CSF1 Protein, Human, Recombinant (His) | Human | Human Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th... | |||
TMPY-00740 | SDF-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-02820 | SDF-1 Protein, Human, Recombinant (isoform a) | Human | E. coli |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-02591 | SDF-1 Protein, Human, Recombinant | Human | E. coli |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-00720 | Contactin 1 Protein, Human, Recombinant (His) | Human | HEK293 |
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3... | |||
TMPY-05296 | IL-34 Protein, Human, Recombinant (His) | Human | CHO |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... | |||
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... | |||
TMPY-00875 | Leptin Protein, Human, Recombinant | Human | E. coli |
Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine, and pro-inflammatory immu... | |||
TMPY-03203 | CD40 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-02121 | CXADR/CAR Protein, Human, Recombinant (His) | Human | HEK293 |
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. ... | |||
TMPY-05775 | Human coronavirus (HCoV-229E) Nucleocapsid Protein (His) | HCoV-229E | E. coli |
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both vi... | |||
TMPY-05766 | Human coronavirus (HCoV-NL63) Nucleocapsid Protein (His) | HCoV-NL63 | E. coli |
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both vi... | |||
TMPJ-01172 | IL-17 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque... | |||
TMPY-05957 | CD40 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05774 | Human coronavirus (HCoV-OC43) Nucleocapsid Protein (His) | HCoV-OC43 | E. coli |
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both vi... | |||
TMPY-01181 | CD40 Protein, Human, Recombinant (His) | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05773 | Human coronavirus (HCoV-HKU1) Nucleocapsid Protein (His) | HCoV-HKU1 | E. coli |
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both vi... | |||
TMPY-00694 | Carbonic Anhydrase 12 Protein, Human, Recombinant (His) | Human | HEK293 |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respi... | |||
TMPY-02899 | Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and... | |||
TMPY-05004 | FGF-4 Protein, Human, Recombinant | Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L7900 | Osteogenesis Compound Library | 317 compounds | |
A unique collection of 317 osteogenesis related compounds for high throughput and high content screening; | |||
L4800 | Angiogenesis related Compound Library | 1353 compounds | |
A unique collection of 1353 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS); | |||
L4710 | Nonsteroidal Anti-Inflammatory Compound Library | 521 compounds | |
521 non-steroidal anti-inflammatory compounds for high-throughput and high-content screening. | |||
L9810 | Anti-Fibrosis Compound Library | 1155 compounds | |
A unique collection of 1155 potential anti-fibrosis compounds, can be used in HTS and HCS; | |||
L3700 | JAK-STAT Compound Library | 252 compounds | |
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening; | |||
L3510 | Methylation Compound Library | 128 compounds | |
128 methylation-related compounds that can be used for high-throughput and high-content screening. | |||
L7500 | Coagulation and Anticoagulation Compound Library | 144 compounds | |
A unique collection of 144 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L1110 | Microtubule-Targeted Compound Library | 142 compounds | |
A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS; | |||
L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); | |||
L9420 | Exosome Compound Library | 76 compounds | |
76 exosome-related compounds that can be used for high-throughput and high-content screening. | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1336 compounds | |
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |