Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 21,500 | |||
25 mg | 在庫あり | ¥ 50,000 | |||
50 mg | 在庫あり | ¥ 90,500 | |||
100 mg | 在庫あり | ¥ 135,000 | |||
500 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. |
In vitro | Iobenguane sulfate is an effective effector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range. Iobenguane sulfate (2-20 μg/ml; 72 hours) suppresses cell growth in a panel of human and mouse leukemia, melanoma, fibrosarcoma, and neuroblastoma cell lines. |
In vivo | Iobenguane sulfate (20 mg/kg; i.p.; daily on days 3-6) displays antitumor activity. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of survival but no cures were observed. |
別名 | MIBG sulfate |
分子量 | 324.13 |
分子式 | C8H10IN3.1/2H2O4S |
CAS No. | 87862-25-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (308.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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