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Search Results for " ubiquitin "

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1431

阻害剤

7

天然化合物

154

リコンビナントタンパク質

1

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カタログ番号 製品名 別名 ターゲット
T17192 Ubiquitin Isopeptidase Inhibitor I, G5 NSC144303 Apoptosis
Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).
T3951 NSC632839 F6,Ubiquitin Isopeptidase Inhibitor II DUB
NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).
T23486 ubiquitin specific protease 3 fragment Others
The ubiquitin speci c protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B.
T24136 Heclin E1/E2/E3 Enzyme
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
T8564 BC-1382 Others , E1/E2/E3 Enzyme
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
T23371 SMER3 SMER 3 Others , Ligand for E3 Ligase
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...
T16102 ML-792 E1/E2/E3 Enzyme
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...
T5199 COH000 E1/E2/E3 Enzyme
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
T16699 PYZD-4409 Others , E1/E2/E3 Enzyme
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
T5374 NAcM-OPT E1/E2/E3 Enzyme , NEDD8
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
T13244 Ubiquitination-IN-1 Others
T12261 NSC232003 E1/E2/E3 Enzyme
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
T16901 SMIP004 Apoptosis , Others , E1/E2/E3 Enzyme
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
T7415 DKM 2-93 E1/E2/E3 Enzyme
DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
T6629 PYR-41 PYR41,PYR 41 Apoptosis , E1/E2/E3 Enzyme
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
T2158 Nutlin-3 Nutlin3 E1/E2/E3 Enzyme
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
T7379 2-D08 E1/E2/E3 Enzyme , TAM Receptor
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T3517 RO8994 Mdm2 , E1/E2/E3 Enzyme , p53
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
T16888 SJ-172550 Mdm2 , E1/E2/E3 Enzyme
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T9236 WSB1 Degrader 1 Others , E1/E2/E3 Enzyme
WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.
T8428 Subasumstat TAK-981 E1/E2/E3 Enzyme
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
T3653 MX69 Mdm2 , E1/E2/E3 Enzyme , IAP
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6149 YH239-EE Apoptosis , E1/E2/E3 Enzyme
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T3317 SZL P1-41 Apoptosis , Others , E1/E2/E3 Enzyme
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...
T11980 MD-224 Mdm2 , E1/E2/E3 Enzyme , PROTACs
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
T7889 C25-140 Others , TNF , E1/E2/E3 Enzyme , NF-κB
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T10703 Mezigdomide CC-92480 Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
T13349 WS-383 E1/E2/E3 Enzyme
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T4253 Skp2 Inhibitor C1 SKPin C1 Others , E1/E2/E3 Enzyme
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
T3110 PRT4165 NSC600157,PRT 4165 BMI-1 , Others , E1/E2/E3 Enzyme
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T5555 Siremadlin NVP-HDM 201 E1/E2/E3 Enzyme
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
T3549 Avadomide CC 122 Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T6254 Idasanutlin RG7388,Ro 5503781 Mdm2 , E1/E2/E3 Enzyme
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T1493 BH3I-1 BHI1 BCL , E1/E2/E3 Enzyme
BH3I-1 (BHI1) is a Bcl-2 antagonist.
T16974 TAK-243 MLN7243 Apoptosis , E1/E2/E3 Enzyme , NF-κB
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...
T6965 RG7112 RG-7112,RG 7112,RO5045337 Mdm2 , E1/E2/E3 Enzyme
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
TQ0231 NVP-CGM097 CGM097 Mdm2 , E1/E2/E3 Enzyme
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
TQ0127 Navtemadlin AMG232,CS-1300 Mdm2 , E1/E2/E3 Enzyme
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T6611 NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran E1/E2/E3 Enzyme
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...
T2243 Serdemetan JNJ-26854165 Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T10268 AGX51 Others
T6023 Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 Apoptosis , E1/E2/E3 Enzyme , Autophagy
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T6585 SAR405838 MI773,MI 773,MI-77301,MI-773 Mdm2 , E1/E2/E3 Enzyme
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
T15729 LDN-91946 DUB
T8929 BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp...
T6614 Nutlin-3b (+)-Nutlin-3 Mdm2 , E1/E2/E3 Enzyme
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
T18064 Lenalidomide-Br Ligand for E3 Ligase
Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a...
T22891 KL001 KL 001,KL-001 Others
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu...
T13273 UT-34 Androgen Receptor
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...

Compounds

Ubiquitin Isopeptidase Inhibitor I, G5
T17192
Synonym: NSC144303
Target: Apoptosis
NSC632839
T3951
Synonym: F6,Ubiquitin Isopeptidase Inhibitor II
Target: DUB
ubiquitin specific protease 3 fragment
T23486
Synonym:
Target: Others
Heclin
T24136
Synonym:
Target: E1/E2/E3 Enzyme
BC-1382
T8564
Synonym:
Target: Others, E1/E2/E3 Enzyme
SMER3
T23371
Synonym: SMER 3
Target: Others, Ligand for E3 Ligase
ML-792
T16102
Synonym:
Target: E1/E2/E3 Enzyme
COH000
T5199
Synonym:
Target: E1/E2/E3 Enzyme
PYZD-4409
T16699
Synonym:
Target: Others, E1/E2/E3 Enzyme
NAcM-OPT
T5374
Synonym:
Target: E1/E2/E3 Enzyme, NEDD8
Ubiquitination-IN-1
T13244
Synonym:
Target: Others
NSC232003
T12261
Synonym:
Target: E1/E2/E3 Enzyme
SMIP004
T16901
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
DKM 2-93
T7415
Synonym:
Target: E1/E2/E3 Enzyme
PYR-41
T6629
Synonym: PYR41,PYR 41
Target: Apoptosis, E1/E2/E3 Enzyme
Nutlin-3
T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
2-D08
T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
RO8994
T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
SJ-172550
T16888
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme
WSB1 Degrader 1
T9236
Synonym:
Target: Others, E1/E2/E3 Enzyme
Subasumstat
T8428
Synonym: TAK-981
Target: E1/E2/E3 Enzyme
MX69
T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
YH239-EE
T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
SZL P1-41
T3317
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
MD-224
T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
C25-140
T7889
Synonym:
Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB
Mezigdomide
T10703
Synonym: CC-92480
Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues
WS-383
T13349
Synonym:
Target: E1/E2/E3 Enzyme
Skp2 Inhibitor C1
T4253
Synonym: SKPin C1
Target: Others, E1/E2/E3 Enzyme
PRT4165
T3110
Synonym: NSC600157,PRT 4165
Target: BMI-1, Others, E1/E2/E3 Enzyme
Siremadlin
T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
Avadomide
T3549
Synonym: CC 122
Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase
Idasanutlin
T6254
Synonym: RG7388,Ro 5503781
Target: Mdm2, E1/E2/E3 Enzyme
BH3I-1
T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
TAK-243
T16974
Synonym: MLN7243
Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB
RG7112
T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
NVP-CGM097
TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
Navtemadlin
TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
NSC697923
T6611
Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Target: E1/E2/E3 Enzyme
Serdemetan
T2243
Synonym: JNJ-26854165
Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53
GS143
T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
AGX51
T10268
Synonym:
Target: Others
Nutlin-3a
T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
SAR405838
T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
LDN-91946
T15729
Synonym:
Target: DUB
BC1618
T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Nutlin-3b
T6614
Synonym: (+)-Nutlin-3
Target: Mdm2, E1/E2/E3 Enzyme
Lenalidomide-Br
T18064
Synonym:
Target: Ligand for E3 Ligase
KL001
T22891
Synonym: KL 001,KL-001
Target: Others
UT-34
T13273
Synonym:
Target: Androgen Receptor
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カタログ番号 製品名 別名 ターゲット
T4S0181 Hinokiflavone MMP , BCL , E1/E2/E3 Enzyme
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...
T9352 Hydrocotarnine Others
hydrocotarnine is an inhibitor of Cbl.
T4036 Solasodine Solancarpidine,Purapuridine,Solasodin Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...
T6S2123 Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1 Others , E1/E2/E3 Enzyme
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
T2947 Indole-3-carbinol I3C,3-Indolemethanol,Indole-3-Methanol E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T75488 Leptosphaerodione
Leptosphaerodione, a compound derived from the Remotididymella sp. fungus, functions as a potent inhibitor of the ubiquitin-proteasome system (UPS) and demonstrates cytotoxic effects in HeLa cells with an IC50 value of 3...
T79941 Antimycin A2c Apoptosis
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces cas...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-02840 Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cl...
TMPY-02331 UCHL1 Protein, Rat, Recombinant (His) Rat E. coli
UCHL1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.2 kDa and the accession number is Q00981.
TMPY-02190 UCHL3 Protein, Mouse, Recombinant (His) Mouse E. coli
UCHL3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.5 kDa and the accession number is Q9JKB1.
TMPY-02332 UCHL3 Protein, Rat, Recombinant (His) Rat E. coli
UCHL3 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.5 kDa and the accession number is Q91Y78.
TMPJ-01047 UBE2H Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei...
TMPY-01548 UCHL3 Protein, Human, Recombinant (His) Human E. coli
UCHL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27 kDa and the accession number is A0A140VJZ4.
TMPJ-01198 UBE2R2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-01035 UBE2G2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPJ-01138 UBE2S Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat...
TMPJ-01038 UBE2K Protein, Human, Recombinant (GST) Human E. coli
UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086.
TMPJ-01403 UBE2D4 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPJ-00033 UBE2B Protein, Human, Recombinant (His) Human HEK293 Cells
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPY-03288 USP30 Protein, Human, Recombinant (SUMO) Human Baculovirus Insect Cells
Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnec...
TMPY-03011 USP46 Protein, Human, Mouse, Recombinant Human,Mouse Baculovirus Insect Cells
USP46 Protein, Human, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.4 kDa and the accession number is P62069.
TMPY-02974 USP46 Protein, Human, Mouse, Recombinant (SUMO) Human,Mouse Baculovirus Insect Cells
USP46 Protein, Human, Mouse, Recombinant (SUMO) is expressed in Baculovirus insect cells with SUMO tag. The predicted molecular weight is 55.2 kDa and the accession number is P62069.
TMPJ-01039 UBE2K Protein, Human, Recombinant (His & SUMO) Human E. coli
UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086.
TMPJ-00571 UBE2D3 Protein, Human, Recombinant Human E. coli
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPJ-00985 UBE2A Protein, Human, Recombinant (GST, His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-01053 UBE2I Protein, Human, Recombinant (GST) Human E. coli
SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPJ-01221 UBE2J2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen...
TMPY-02605 UBE2F Protein, Human, Recombinant (His) Human E. coli
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPJ-00999 UBE2D1 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPJ-01334 UBE2Z Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPY-01547 UCHL1 Protein, Human, Recombinant (His) Human E. coli
UCHL1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P09936.
TMPY-02211 USP5 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 famil...
TMPY-02175 UCHL1 Protein, Mouse, Recombinant (His) Mouse E. coli
UCHL1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.2 kDa and the accession number is Q9R0P9.
TMPK-01001 RNF43 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPY-00361 Pellino-1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce...
TMPY-04263 UBE2T Protein, Human, Recombinant (His) Human E. coli
Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locate...
TMPY-06325 USP14 Protein, Human, Recombinant (His) Human E. coli
USP14 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 56.9 kDa and the accession number is NP_005142.1.
TMPY-02604 UBE2D4 Protein, Human, Recombinant (His) Human E. coli
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPJ-01022 SUMO3 Protein, Human, Recombinant (HEK293, His) Human HEK293 Cells
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way...
TMPY-02608 UBC9/UBE2I Protein, Human, Recombinant Human E. coli
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02642 UBE2W Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPY-02609 UBE2M Protein, Human, Recombinant Human E. coli
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPJ-01021 SUMO3 Protein, Human, Recombinant Human E. coli
SUMO3 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 KDa and the accession number is P55854.
TMPY-02606 UBE2G1 Protein, Human, Recombinant Human E. coli
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His) Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPJ-01023 SUMO3 Protein, Human, Recombinant (E.coli, His) Human E. coli
SUMO3 Protein, Human, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is P55854.
TMPY-02522 OTUB2 Protein, Human, Recombinant (His) Human E. coli
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1...
TMPJ-01324 UBA5 Protein, Human, Recombinant (His) Human E. coli
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. T...
TMPY-01463 USP7 Protein, Human, Recombinant (aa 208-560, His & GST) Human Baculovirus Insect Cells
USP7 Protein, Human, Recombinant (aa 208-560, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.8 kDa and the accession number is Q93009-1.
TMPY-01464 USP7 Protein, Human, Recombinant (aa 208-560) Human Baculovirus Insect Cells
USP7 Protein, Human, Recombinant (aa 208-560) is expressed in Baculovirus insect cells. The predicted molecular weight is 41 kDa and the accession number is Q93009-1.
TMPY-01465 USP7 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
USP7 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 156 kDa and the accession number is Q93009-1.
TMPY-00611 UBE2B Protein, Mouse, Recombinant Mouse E. coli
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPY-02496 Rad6/UBE2A Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPJ-00486 SUMO2 Protein, Human, Recombinant (His) Human E. coli
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p...
TMPY-02214 OTUB1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...
TMPJ-00495 ISG15 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protei...
TMPY-06748 UBA6 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homo...
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Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)
TMPY-02840
Species: Human
Expression System: Baculovirus Insect Cells
UCHL1 Protein, Rat, Recombinant (His)
TMPY-02331
Species: Rat
Expression System: E. coli
UCHL3 Protein, Mouse, Recombinant (His)
TMPY-02190
Species: Mouse
Expression System: E. coli
UCHL3 Protein, Rat, Recombinant (His)
TMPY-02332
Species: Rat
Expression System: E. coli
UBE2H Protein, Human, Recombinant (GST)
TMPJ-01047
Species: Human
Expression System: E. coli
UCHL3 Protein, Human, Recombinant (His)
TMPY-01548
Species: Human
Expression System: E. coli
UBE2R2 Protein, Human, Recombinant (His)
TMPJ-01198
Species: Human
Expression System: E. coli
UBE2G2 Protein, Human, Recombinant (GST)
TMPJ-01035
Species: Human
Expression System: E. coli
UBE2S Protein, Human, Recombinant (GST)
TMPJ-01138
Species: Human
Expression System: E. coli
UBE2K Protein, Human, Recombinant (GST)
TMPJ-01038
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (GST)
TMPJ-01403
Species: Human
Expression System: E. coli
UBE2B Protein, Human, Recombinant (His)
TMPJ-00033
Species: Human
Expression System: HEK293 Cells
USP30 Protein, Human, Recombinant (SUMO)
TMPY-03288
Species: Human
Expression System: Baculovirus Insect Cells
USP46 Protein, Human, Mouse, Recombinant
TMPY-03011
Species: Human,Mouse
Expression System: Baculovirus Insect Cells
USP46 Protein, Human, Mouse, Recombinant (SUMO)
TMPY-02974
Species: Human,Mouse
Expression System: Baculovirus Insect Cells
UBE2K Protein, Human, Recombinant (His & SUMO)
TMPJ-01039
Species: Human
Expression System: E. coli
UBE2D3 Protein, Human, Recombinant
TMPJ-00571
Species: Human
Expression System: E. coli
UBE2A Protein, Human, Recombinant (GST, His)
TMPJ-00985
Species: Human
Expression System: E. coli
UBE2I Protein, Human, Recombinant (GST)
TMPJ-01053
Species: Human
Expression System: E. coli
UBE2J2 Protein, Human, Recombinant (GST)
TMPJ-01221
Species: Human
Expression System: E. coli
UBE2F Protein, Human, Recombinant (His)
TMPY-02605
Species: Human
Expression System: E. coli
UBE2D1 Protein, Human, Recombinant (GST)
TMPJ-00999
Species: Human
Expression System: E. coli
UBE2Z Protein, Human, Recombinant (His)
TMPJ-01334
Species: Human
Expression System: E. coli
UCHL1 Protein, Human, Recombinant (His)
TMPY-01547
Species: Human
Expression System: E. coli
USP5 Protein, Human, Recombinant (His)
TMPY-02211
Species: Human
Expression System: Baculovirus Insect Cells
UCHL1 Protein, Mouse, Recombinant (His)
TMPY-02175
Species: Mouse
Expression System: E. coli
RNF43 Protein, Mouse, Recombinant (hFc)
TMPK-01001
Species: Mouse
Expression System: HEK293 Cells
Pellino-1 Protein, Human, Recombinant (His & GST)
TMPY-00361
Species: Human
Expression System: Baculovirus Insect Cells
UBE2T Protein, Human, Recombinant (His)
TMPY-04263
Species: Human
Expression System: E. coli
USP14 Protein, Human, Recombinant (His)
TMPY-06325
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (His)
TMPY-02604
Species: Human
Expression System: E. coli
SUMO3 Protein, Human, Recombinant (HEK293, His)
TMPJ-01022
Species: Human
Expression System: HEK293 Cells
UBC9/UBE2I Protein, Human, Recombinant
TMPY-02608
Species: Human
Expression System: E. coli
UBE2W Protein, Human, Recombinant (His)
TMPY-02642
Species: Human
Expression System: E. coli
UBE2M Protein, Human, Recombinant
TMPY-02609
Species: Human
Expression System: E. coli
SUMO3 Protein, Human, Recombinant
TMPJ-01021
Species: Human
Expression System: E. coli
UBE2G1 Protein, Human, Recombinant
TMPY-02606
Species: Human
Expression System: E. coli
UBE2L6 Protein, Human, Recombinant (His)
TMPY-02842
Species: Human
Expression System: E. coli
SUMO3 Protein, Human, Recombinant (E.coli, His)
TMPJ-01023
Species: Human
Expression System: E. coli
OTUB2 Protein, Human, Recombinant (His)
TMPY-02522
Species: Human
Expression System: E. coli
UBA5 Protein, Human, Recombinant (His)
TMPJ-01324
Species: Human
Expression System: E. coli
USP7 Protein, Human, Recombinant (aa 208-560, His & GST)
TMPY-01463
Species: Human
Expression System: Baculovirus Insect Cells
USP7 Protein, Human, Recombinant (aa 208-560)
TMPY-01464
Species: Human
Expression System: Baculovirus Insect Cells
USP7 Protein, Human, Recombinant (His & GST)
TMPY-01465
Species: Human
Expression System: Baculovirus Insect Cells
UBE2B Protein, Mouse, Recombinant
TMPY-00611
Species: Mouse
Expression System: E. coli
Rad6/UBE2A Protein, Human, Recombinant (His)
TMPY-02496
Species: Human
Expression System: E. coli
SUMO2 Protein, Human, Recombinant (His)
TMPJ-00486
Species: Human
Expression System: E. coli
OTUB1 Protein, Human, Recombinant (His)
TMPY-02214
Species: Human
Expression System: E. coli
ISG15 Protein, Human, Recombinant (His)
TMPJ-00495
Species: Human
Expression System: E. coli
UBA6 Protein, Human, Recombinant (GST)
TMPY-06748
Species: Human
Expression System: Baculovirus Insect Cells
カタログ番号 製品名
L8600 Ubiquitination Compound Library

210 compounds
A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening;