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T32419 |
KRAS4b-PDEδ stabilizer C19
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|
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KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling. |
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T72286 |
LC kinetic stabilizer-2
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|
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LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM. |
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T72285 |
LC kinetic stabilizer-1
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LC kinetic stabilizer-1 is a potent, selective kinetic stabilizer for amyloidogenic immunoglobulin light chains, demonstrating EC50 values of 140 nM for WIL-FL* and 74.1 nM for WIL-FL*T46L/F49Y, respectively. Notably, WI... |
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T32500 |
L6Y
|
TTR stabilizer L6 |
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L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer. |
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T33261 |
MDK-5432
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AMPA stabilizer (R,R)-2a,MDK 5432 |
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MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer. |
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T79736 |
14-3-3σ/ERα stabilizer-1
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Estrogen Receptor/ERR
|
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Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue [1]. |
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T8239 |
Cromoglicic acid
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|
Others
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Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. |
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T22891 |
KL001
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KL 001,KL-001 |
Others
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KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu... |
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T60028 |
MM41
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DNA/RNA Synthesis
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MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line. |
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T12678 |
(Rac)-Telmesteine
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3-(Ethoxycarbonyl)thiazolidine-4-carboxylic acid,3-ethoxycarbonyl-1,3-thiazolidine-4-carboxylic acid,3,4-Thiazolidinedicarboxylic Acid 3-Ethyl Ester |
Protease
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(Rac)-Telmesteine (3,4-Thiazolidinedicarboxylic Acid 3-Ethyl Ester) is an inhibitor of protease and is thus a suitable enzyme stabilizer. |
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T4457 |
Pyridostatin Trihydrochloride
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Pyridostatin Trihydrochloride(free base 1085412-37-8 ),RR-82 Trihydrochloride |
DNA/RNA Synthesis
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Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
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T21282 |
Topanol CA
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|
Others
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Topanol CA is a bioactive chemical. |
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T7582 |
Tafamidis meglumine
|
Fx-1006A |
Others
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Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade |
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T15772 |
Lodoxamide tromethamine
|
U-42585E |
Histamine Receptor
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Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis. |
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T6488 |
Epinastine hydrochloride
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Alesion,Epinastine HCl,WAL-801CL HCl,Elestat |
5-HT Receptor
,
Histamine Receptor
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Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
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T0211 |
Azelastine
|
Azelastina,Astelin,Azelastinum |
SARS-CoV
,
Histamine Receptor
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|
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T0008 |
Phenytoin sodium
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5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium |
Virus Protease
,
Sodium Channel
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Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel . |
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T1899 |
Pyridostatin
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RR82,Pyridostatin Trifluoroacetate Salt |
DNA/RNA Synthesis
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Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. |
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T9447 |
AG-10
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Acoramidis |
Others
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AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis. |
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T4566 |
Lodoxamide
|
Lodoxamidum |
GPR
,
Histamine Receptor
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Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis. |
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T26955 |
Cavosonstat
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N91115,N 91115,N-91115 |
GSNOR
,
CFTR
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Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ... |
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T9526 |
Polysorbate 20
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Tween-20 |
Others
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Polysorbate 20 (Tween-20) ,sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives, is used in the formulation of biotherapeutic products for both preventing surface adsorption and as a stabilizer against pro... |
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T21648 |
CP-31398 dihydrochloride
|
CP 31398 dihydrochloride |
p53
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CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
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T9608 |
KL201
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Others
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KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
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T0404 |
8-Hydroxyquinoline
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Hydroxyquinoline,8-Quinolinol,Oxine,8-Oxychinolin |
Others
,
Antibacterial
,
Antibiotic
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8-Hydroxyquinoline (8-Quinolinol) is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes adde... |
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T7352 |
Pridopidine
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ACR16,ASP2314,FR310826 |
Dopamine Receptor
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Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model. |
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T0680 |
Lamotrigine
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LTG,BW430C |
5-HT Receptor
,
Sodium Channel
,
Autophagy
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Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
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T39740 |
Acoramidis hydrochloride
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AG10 hydrochloride,Alxn2060 hydrochloride |
Others
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Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis. |
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T17217 |
Vamorolone
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VBP15 |
Glucocorticoid Receptor
,
NF-κB
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Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition an... |
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T33816 |
Ordopidine
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ACR-325,ACR 325,ACR325 |
Dopamine Receptor
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Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and... |
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T19820 |
MOPS sodium salt
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MOPS-Na,3-(N-morpholino)propanesulfonic acid sodium salt,Sodium 3-Morpholinopropanesulfonate,4-Morpholinepropanesulfonic acid, sodium salt |
Others
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MOPS sodium salt (MOPS-Na) is a novel stabilizer maintaining the pH of mammalian cell culture media. It used as a buffer for the native structure of BSA against thermal denaturation.MOPS sodium salt(3-(N-morpholino)propa... |
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T4470 |
Pyridostatin TFA
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DNA/RNA Synthesis
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Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
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T21300 |
Trientine-2HCl
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Triethylenetetramine,Trientine HCl,Trientine,Triethylene tetramine,TETA,Trien |
Others
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Trientine-2HCl (Trien), a chelating agent, is used to treat Wilson's disease by binding up and removing copper in the body. Trientine can also be used as a chelating agent for copper in hepatolenticular degeneration, as ... |
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TF0106 |
Cholesteryl Hemisuccinate Tris Salt
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Apoptosis
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Cholesteryl Hemisuccinate Tris Salt is an acidic cholesteryl ester with hepatoprotective and anticancer activity.Cholesteryl hemisuccinate is a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing C... |
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T4565 |
Tafamidis
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Fx-1006A |
Others
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Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di... |
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T35841 |
5-Benzyloxygramine
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Dopamine Receptor
,
5-HT Receptor
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5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].
5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter... |
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T34759 |
Synstab A
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Synstab-A |
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Synstab A is a microtubule stabilizer. |
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T35319 |
Zy 15109
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N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate |
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Zy 15109 can be used as inhaled mast cell stabilizer. |
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T19212 |
BMVC2
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o-BMVC |
Others
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BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer. |
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T23114 |
OSU 6162 hydrochloride
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Others
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Dopamine stabilizer |
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T20598 |
Sorbitan monolaurate
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Emasol L 10,Emasol L-10,Arlacel20,Arlacel-20,Arlacel 20,Emasol L10 |
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Sorbitan monolaurate, a non-ionic surfactant, is widely used as a stabilizer and emulsifier in pharmaceutical formulations, food, and cosmetic industries. |
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T30587 |
Brl 22321
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Brl22321,Brl-22321 |
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Brl 22321 is a mast cell stabilizer. |
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T71626 |
Epibestatin Hydrochloride
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Epibestatin Hydrochloride is a stabilizer of 14-3-3 PPIs, as well as a diastereoepimer of aminopeptidase inhibitor bestatin. |
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T31364 |
Dehydelone
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KOS1584,SK-10088,KOS-1584,R-1645,SK10088,R1645 |
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Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer. |
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T26391 |
5HPP-33
|
5HPP33 |
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5HPP-33 is an microtubule-stabilizer with the properties of antiproliferative and antimitotic. |
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T29468 |
61A2
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61-A-2,61 A 2 |
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61A2, known as a stabilizer of the active LPL dimer can prevents LPL inactivation. |
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T69584 |
GMC-1111 dihydrochloride
|
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GMC-1111 dihydrochloride is a dopamine partial agonist and stabilizer. |
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T69585 |
GMC-1111 free base
|
|
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GMC-1111 free base is a dopamine partial agonist and stabilizer. |
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T20780 |
Dibutyltin maleate
|
Stavinor Sn 1300,Stavinor 1300SN |
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Dibutyltin maleate is used as a condensation catalyst and pvc Stabilizer. |
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T19472 |
Nedocromil sodium
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Nedocromil disodium salt,FPL 59002KP |
Others
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|
Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling. |
