Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 49,000 |
2 mg | 在庫あり | ¥ 68,500 |
5 mg | 在庫あり | ¥ 104,500 |
10 mg | 在庫あり | ¥ 154,500 |
25 mg | 在庫あり | ¥ 243,500 |
50 mg | 在庫あり | ¥ 328,500 |
100 mg | 在庫あり | ¥ 441,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 131,500 |
説明 | LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively). |
ターゲット&IC50 | LDHB:27 nM (IC50), LDHA:32 nM (IC50) |
In vitro | LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells. |
In vivo | LDH-IN-1 exhibits clearance rates significantly surpassing those of hepatic blood flow in mice (90 mL/min/kg), demonstrating an in vivo clearance of 227 mL/min/kg[1]. |
分子量 | 570.68 |
分子式 | C30H26N4O4S2 |
CAS No. | 1964515-43-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (87.61 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LDH-IN-1 1964515-43-2 Metabolism Dehydrogenase Lactate Dehydrogenase inhibit LDH LDH IN 1 Inhibitor LDHIN1 inhibitor