Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
説明 | LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. |
In vitro | LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining [2]. |
In vivo | After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent [2]. |
別名 | LDN-0212320, LDN/OSU-0212320, OSU-0212320 |
分子量 | 293.39 |
分子式 | C17H15N3S |
CAS No. | 894002-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (56.81 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LDN-212320 894002-50-7 Metabolism transporter Glutamate transporter 1 inhibit EAAT2 LDN/OSU 0212320 LDN/OSU0212320 LDN 0212320 Inhibitor LDN-0212320 LDN 212320 OSU 0212320 OSU0212320 LDN0212320 GLT-1 Excitatory amino acid transporter 2 LDN212320 LDN/OSU-0212320 OSU-0212320 inhibitor